2024 年第 2 期 第 19 卷

阿司匹林反应性检测方法与影响因素的研究进展

Advances in detective method and related factors of aspirin responsiveness

作者：张嘉祺王茜婷陈夏欢刘梅林

英文作者：Zhang Jiaqi Wang Xiting Chen Xiahuan Liu Meilin

单位：北京大学第一医院老年病内科，北京100034

英文单位：Department of Geriatrics Peking University First Hospital Beijing 100034 China

关键词：阿司匹林反应性；血小板；个体化治疗；心血管疾病

英文关键词：Aspirinresponsiveness;Platelets;Personalizedtreatment;Cardiovasculardisease

• 摘要：

• 阿司匹林是一种常用的抗血小板治疗药物，广泛应用于心血管疾病的预防。尽管阿司匹林已被证实能显著改善心血管疾病患者的临床结局，但临床实践中始终有部分患者服用阿司匹林后仍发生血栓事件，无法达到预期的抗血小板治疗效果，提示阿司匹林反应性存在个体差异。近年来研究发现，阿司匹林反应性调控受多种因素影响，且阿司匹林反应性的检测方法逐步完善。本文综述了阿司匹林反应性的定义、检测方法、影响因素以及相关基因的研究进展，对进一步探索阿司匹林反应性的调控机制，实现阿司匹林的个体化、精准化治疗，提高心血管疾病的预防效果具有重要意义。

• Aspirin is a widely used antiplatelet therapy for preventive cardiovascular treatment. Although it has demonstrated significant improvement in clinical outcomes for patients with cardiovascular diseases, a subset of patients do not experience the expected antiplatelet effects and may still suffer thrombotic events despite aspirin treatment. This suggests individual variability in aspirin responsiveness. Recent researcheshaveidentified multiple factors that regulate aspirin responsiveness and refined detection methods. This article provides an overview of the latest advancements in the definition, detection methods, influencing factors, and associated genes related to aspirin responsiveness. These findings are essential for further exploration of the underlying mechanisms, development of individualized and precise aspirin treatment, and enhancement of preventive measures for cardiovascular diseases.