2023 年第 11 期 第 18 卷

参附注射液联合加贝酯治疗急性胰腺炎的临床效果研究

Clinical effect of Shenfu injection combined with gabexate in the treatment of acute pancreatitis

作者：李冠东江磊周逸坤王美堂

英文作者：Li Guandong Jiang Lei Zhou Yikun Wang Meitang

单位：海军军医大学第一附属医院急诊科，上海200433

英文单位：Department of Emergency the First Affiliated Hospital of Naval Medical University Shanghai 200433 China

关键词：急性胰腺炎；参附注射液；加贝酯；胰腺血流动力学；血细胞功能；药物安全性

英文关键词：Acutepancreatitis;Shenfuinjection;Gabexate;Pancreatichemodynamics;Bloodcellfunction;Drugsafety

• 摘要：

• 目的  探讨参附注射液联合加贝酯治疗急性胰腺炎的临床效果。方法  选取2020年7月至2022年11月海军军医大学第一附属医院收治的83例急性胰腺炎患者，按照随机数字表法分为观察组（42例）和对照组（41例）。对照组静脉滴注注射用甲磺酸加贝酯治疗；观察组在对照组基础上给予参附注射液静脉滴注治疗，2组均治疗7 d后统计疗效。比较2组患者症状体征的消失时间。检测2组患者血清红细胞体积分布宽度(RDW)、血小板体积分布宽度（PDW）、平均血小板体积(MPV)水平。对比2组的胰腺血流动力学指标血容量、血流量、表面通透性（PS）。评估2组的药物安全性。结果  治疗7 d后，观察组总有效率明显高于对照组［95.2%（40/42）比80.5%（33/41）］（P＜0.05）。观察组腹痛消退时间、血淀粉酶恢复时间、胃肠减压时间、肠鸣音恢复时间均短于对照组（均P＜0.05）。2组治疗后的RDW、PDW、MPV均明显小于治疗前，且观察组均小于对照组（均P＜0.05）。2组治疗后的胰腺血流动力学指标血容量、血流量高于治疗前，PS低于治疗前，观察组的血容量、血流量高于对照组，PS低于对照组（均P＜0.05）。2组不良反应发生率比较差异无统计学意义（P＞0.05）。结论  参附注射液联合加贝酯可提高急性胰腺炎的疗效，进一步提高症状改善效率，改善胰腺血流动力学水平和血细胞功能，且药物安全性良好。

• Objective  To investigate the clinical effect of Shenfu injection combined with gabexate in the treatment of acute pancreatitis. Methods  Totally 83 patients with acute pancreatitis admitted to the First Affiliated Hospital of Naval Medical University from July 2020 to November 2022 were selected, and they were divided into observation group (42 cases) and control group (41 cases) according to the random number table method. The patients in the control group were treated with intravenous gabexate mesylate for injection, and the patients in the observation group were treated with intravenous infusion of Shenfu injection on the basis of the control group. After 7 d of treatment, the curative effect of the two groups was statistically analyzed. The disappearance times of symptoms and signs were compared between the two groups. Serum red cell volume distribution width (RDW), platelet distribution width (PDW) and mean platelet volume (MPV) levels were detected between the two groups. The pancreatic hemodynamic indicators of blood volume, blood flow and surface permeability (PS) were compared between the two groups. The drug safety of the two groups was evaluated. Results  After 7 d of treatment, the total effective rate of the observation group was significantly higher than that of the control group［95.2%（40/42） vs 80.5%（33/41）］（P＜0.05）. The abdominal pain regression time, blood amylase recovery time, gastrointestinal decompression time and bowel sound recovery time of the observation group were shorter than those of the control group (all P＜0.05). The RDW, PDW and MPV of the two groups after treatment were significantly lower than those before treatment, and those of the observation group were lower than those of the control group (all P＜0.05). The pancreatic hemodynamic indicators of blood volume and blood flow of the two groups after treatment were higher than those before treatment, and the PS was lower than that before treatment, the blood volume and blood flow of the observation group were higher than those of the control group, and the PS was lower than that of the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusions    henfu injection combined with gabexate can improve the efficacy of acute pancreatitis, further improve the efficiency of symptom improvement, improve the level of pancreatic hemodynamics and blood cell function, and the drug safety is good.