2023 年第 3 期 第 18 卷

免疫检查点抑制剂相关性肺炎的研究进展

Research progress on immune checkpoint inhibitors-related pneumonitis

作者：张艳琳1李伟2刘丹1

英文作者：Zhang Yanlin1 Li Wei2 Liu Dan1

单位：1四川大学华西医院呼吸与危重症医学科，成都610044；2四川省宜宾市第二人民医院病理科，宜宾644000

英文单位：1Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University Chengdu 610044 China; 2Department of Pathology the Second People′s Hospital of Yibin Sichuan Province Yibin 644000 China

关键词：免疫检查点抑制剂；免疫相关性肺炎；发病机制；治疗

英文关键词：Immunecheckpointinhibitors;Immunerelatedpneumonitis;Pathogenesis;Treatment

• 摘要：

• 目前，恶性肿瘤治疗方式多元化，由于免疫检查点抑制剂（ICIs）能够改善患者生存质量和延长患者生存时间，近年来在恶性肿瘤治疗中得到推广应用。随着应用的日益广泛，免疫治疗过程中出现的一系列不良反应事件，近年来也得到临床越来越多的关注。其中，ICIs相关性肺炎（CIP）是免疫治疗过程中严重的肺损伤，也是导致接受ICIs治疗患者死亡的原因之一。本文收集整理国内外相关研究资料，重点对CIP的发病情况、发病机制、临床特征、影像学表现、诊治要点等资料作一综述，为临床早期监测、早期诊断、鉴别诊断、合理治疗提供科学依据。

• At present, the treatment of malignant tumors is diversity, immune checkpoint inhibitors (ICIs) have been widely used in malignant tumors in recent years, and they have played a positive role in improving the quality of life and prolong the survival time of patients. However, with the gradual wide application, a series of adverse reactions in immunotherapy have been paid more and more attention in clinical practice in recent years. Among them, ICIs-related pneumonitis（CIP） is a serious pulmonary injury in immunotherapy, which is also one of the causes of death in patients treated with ICIs. Therefore, this paper collects and sorts out relevant research data at home and abroad, focusing on the incidence, pathogenesis, clinical characteristics, imaging manifestations, diagnosis and treatment of CIP, in order to explore the key points of recognition and diagnosis of CIP, and to provide scientific basis for early clinical monitoring, differential diagnosis and reasonable treatment.