2023 年第 1 期 第 18 卷

基质金属蛋白酶9在非小细胞肺癌中的研究进展

Research progress of matrix metalloproteinase-9 in non-small cell lung cancer

作者：叶其淼1李建强2

英文作者：Ye Qimiao1 Li Jianqiang2

单位：1山西医科大学第二临床医学院，太原030001；2山西医科大学第二医院呼吸与危重症医学科，太原030001

英文单位：1The Second Clinical Medical College of Shanxi Medical University Taiyuan 030001 China; 2Department of Respiratory and Critical Care Medicine Second Hospital of Shanxi Medical University Taiyuan 030001 China

关键词：非小细胞肺癌；基质金属蛋白酶9；侵袭和转移；血管生成

英文关键词：Non-smallcelllungcancer;Matrixmetalloproteinase-9;Invasionandmetastasis;Angiogenesis

• 摘要：

• 基质金属蛋白酶9(MMP-9)广泛参与机体内细胞外基质降解和重塑的生理功能，而且研究发现MMP-9与恶性肿瘤进展和转移有关，通过介导肿瘤微环境，在肿瘤的发生、发展中扮演着重要角色。MMP-9在非小细胞肺癌（NSCLC）中的异常表达，与NSCLC细胞增殖、血管生成、侵袭和转移有密切关系，可以作为临床诊断、靶向治疗和患者预后的标志物，在NSCLC中靶向MMP-9具有很高的研究价值和作用，本文就MMP-9在NSCLC中的作用及研究进展作一综述。

• Matrix metalloproteinase-9 (MMP-9) is widely involved in the physiological functions of extracellular matrix degradation and remodeling in the body. Studies have found that MMP-9 is related to the progression and metastasis of malignant tumors, and plays an important role in the occurrence and development of tumors by mediating tumor microenvironment. Abnormal expression of MMP-9 in non-small cell lung cancer (NSCLC) is closely related to NSCLC cell proliferation, angiogenesis, invasion and metastasis, which can be used as a marker for clinical diagnosis, targeted therapy and patient prognosis. Targeting MMP-9 in NSCLC has high research value and effect. This article reviews the role and research progress of MMP-9 in NSCLC.