2022 年第 4 期 第 17 卷

血清骨膜蛋白水平与2型糖尿病合并动脉粥样硬化性心血管疾病的相关性分析

Relationship between the level of serum periosteal protein and type 2 diabetes mellitus complicated with atherosclerotic cardiovascular diseases

作者：董俐1罗晓红1万东君2马凌3贾春晖1许瑞元1王春雨1

英文作者：Dong Li1 Luo Xiaohong1 Wan Dongjun2 Ma Ling3 Jia Chunhui1 Xu Ruiyuan1 Wang Chunyu1

单位：1中国人民解放军联勤保障部队第九四〇医院内分泌科，兰州730050；2中国人民解放军联勤保障部队第九四〇医院神经内科，兰州730050；3中国人民解放军联勤保障部队第九四〇医院心内科，兰州730050

英文单位：1Department of Endocrinology the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army Lanzhou 730050 China; 2Department of Neurology the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army Lanzhou 730050 China; 3Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army Lanzhou 730050 China

关键词：2型糖尿病；骨膜蛋白；动脉粥样硬化性心血管疾病

英文关键词：Type2diabetesmellitus;Periosteumprotein;Atheroscleroticcardiovasculardisease

• 摘要：

• 目的 探讨2型糖尿病（T2DM）患者血清骨膜蛋白水平与动脉粥样硬化性心血管疾病（ASCVD）的相关性。方法 选取2021年1—7月在中国人民解放军联勤保障部队第九四〇医院住院的133例受试者作为观察群体，根据患病情况分为T2DM组（30例）、ASCVD组（32例）、T2DM合并非急性ASCVD组（33例）和T2DM合并急性ASCVD组（38例），另选取同期本院体检中心的20名健康志愿者作为健康对照组。收集所有受试者的一般情况、心脑血管病史及生化指标等相关临床资料。采用酶联免疫吸附试验法检测这些受试者血清骨膜蛋白的水平。采用Pearson相关分析方法分析血清骨膜蛋白水平与其他指标的相关性。采用二元Logistic回归分析方法探讨T2DM合并ASCVD的影响因素。采用受试者工作特征曲线评价血清骨膜蛋白在各组中的诊断效能。结果 T2DM组、ASCVD组、T2DM合并非急性ASCVD组及T2DM合并急性ASCVD组血清骨膜蛋白水平均显著高于健康对照组（均P<0.05）。相关性分析结果显示，骨膜蛋白水平与年龄（r=0.361，P<0.010）、空腹血糖（r=0.224，P<0.010）、糖化血红蛋白（r=0.335，P<0.010）、糖化血清蛋白（r=0.288，P<0.010）、总胆固醇（r=0.196，P<0.010）、高密度脂蛋白胆固醇（r=0.172，P=0.030）呈正相关。Logistic回归分析结果显示，女性、年龄增长及高表达的血清骨膜蛋白水平为T2DM合并ASCVD的危险因素（均P<0.05）。血清骨膜蛋白对T2DM、ASCVD、T2DM合并非急性或急性ASCVD均有诊断价值（均P<0.05）。结论 血清骨膜蛋白水平升高是T2DM患者发生ASCVD的危险因素。血清骨膜蛋白对T2DM、ASCVD、T2DM合并ASCVD的诊断均具有一定的特异度和敏感度。

• Objective To investigate the relationship between the level of serum periosteal protein and atherosclerotic cardiovascular diseases (ASCVD) in patients with type 2 diabetes mellitus(T2DM). Methods Totally 133 subjects admitted to the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army from January to July 2021 were enrolled. According to the prevalence of diseases, they were divided into T2DM group(30 cases), ASCVD group(32 cases), T2DM combined with non acute ASCVD group(33 cases) and T2DM combined with acute ASCVD group(38 cases). In addition, 20 healthy volunteers from the physical examination center of the hospital were selected as the healthy control group. The general information, cardiovascular and cerebrovascular history and biochemical indicators of all subjects were collected. The level of serum periosteal protein was measured by enzyme linked immunosorbent assay. Pearson correlation analysis was used to analyze the correlation between level of serum periosteum protein and other indicators. The binary Logistic regression analysis was used to analyze the influencing factors of T2DM complicated with ASCVD. The diagnostic efficacy of serum periosteal protein in each group was evaluated by the receiver operating characteristic (ROC) curve. Results The level of serum periosteal protein in T2DM group, ASCVD group, T2DM combined with non acute ASCVD group and T2DM combined with acute ASCVD group was significantly higher than that in healthy control group(all P<0.05). Correlation analysis showed that periosteal protein level was positively correlated with age(r=0.361, P<0.010), fasting blood glucose(r=0.224, P<0.010), glycosylated hemoglobin(r=0.335, P<0.010), glycosylated serum protein(r=0.288, P<0.010), total cholesterol(r=0.196, P<0.010) and high-density lipoprotein cholesterol(r=0.172, P=0.030). Logistic regression analysis showed that women, age growth and high expression of serum periosteal protein were the risk factors of T2DM combined with ASCVD(all P<0.05). Serum periosteal protein was valuable in the diagnosis of T2DM, ASCVD, and T2DM comlined with non acute or acute ASCVD(all P<0.05). Conclusions Elevated level of serum periosteal protein is a risk factor for ASCVD in patients with T2DM. Serum periosteal protein has certain specificity and sensitivity in the diagnosis of T2DM, ASCVD and T2DM combined with ASCVD.