2020 年第 10 期 第 15 卷

维生素A和维生素D及维生素E与儿童反复呼吸道感染的相关性研究

Association between serum vitamin A, vitamin D， vitamin E levels and recurrent respiratory tract infection in children 

作者：白英杰黄姗姗汪云

英文作者：Bai Yingjie Huang Shanshan Wang Yun

单位：北京市中西医结合医院儿科100039

英文单位：Department of Pediatrics Beijing Hospital of Integrated Traditional Chinese and Western Medicine Beijing 100039 China

关键词：儿童反复呼吸道感染；维生素A；维生素D；维生素E

英文关键词：Recurrentrespiratorytractinfectioninchildren;VitaminA;VitaminD;VitaminE

• 摘要：

• 目的 探讨维生素A、维生素D和维生素E与儿童反复呼吸道感染的相关性。方法 选取2016年8月8日至2019年10月27日北京市中西医结合医院儿科门诊收治的反复呼吸道感染患儿366例为反复感染组，选取同期本院早教中心的正常体检健康儿童503名为对照组。采用液相色谱串联质谱检测技术测定2组儿童血清维生素A、维生素D和维生素E含量，其中维生素D包括25羟维生素D［25-（OH）D］和25羟维生素D3［25-（OH）D3］，比较2组血清维生素A、维生素D和维生素E水平和缺乏情况，并分析反复感染组患儿血清维生素A、维生素E和维生素D缺乏在不同年龄段的分布情况。结果 反复感染组血清维生素A、维生素E、25-（OH）D3、25-（OH）D水平均明显低于对照组［（0.29±0.08）mg/L比（0.31±0.07）mg/L、（8.2±2.0）mg/L比（9.6±2.5）mg/L、（27±9）μg/L比（36±9）μg/L、（26±9）μg/L比（36±9）μg/L］（均P＜0.05）。反复感染组维生素A、维生素E和25-（OH）D3、25-（OH）D缺乏检出率均明显高于对照组（均P＜0.05）。1～3岁组反复呼吸道感染患儿维生素A、25-（OH）D3和25-（OH）D缺乏检出率明显高于＜1岁组和＞3岁组（均P＜0.05）。不同年龄反复感染组患儿维生素E缺乏检出率比较，差异无统计学意义（P＞0.05）。结论 反复呼吸道感染患儿维生素A、维生素D和维生素E含量明显降低，适量补充相关维生素可能会减低儿童呼吸道感染的发病率。

• Objective To explore the relationship between serum vitamin A, vitamin D， vitamin E levels and recurrent respiratory tract infection in children. Methods From August 8, 2016 to October 27, 2019, 366 children with recurrent respiratory tract infection  admitted to Beijing Hospital of Integrated Traditional Chinese and Western Medicine were selected as the recurrent infection group, and 503 healthy children in the early childhood education center of Beijing Hospital of Integrated Traditional Chinese and Western Medicine were selected as the control group. The contents of vitamin A, vitamin D ［including 25-（OH）D and 25-（OH）D3］ and vitamin E in serum of two groups were determined by liquid mass spectrometry. The serum vitamin A, vitamin D and vitamin E levels were compared between the two groups, and the distribution of vitamin A, vitamin E and vitamin D deficiency in different age groups were analyzed. Results The serum vitamin A, vitamin E and 25-（OH）D3, 25-（OH）D level in the recurrent infection group were significantly lower than those in the control group ［（0.29±0.08）mg/L vs （0.31±0.07）mg/L,（8.2±2.0）mg/L vs （9.6±2.5）mg/L,（27±9）μg/L vs （36±9）μg/L,（26±9）μg/L vs （36±9）μg/L］（all P＜0.05）. The detection rate of vitamin A, vitamin E and 25-（OH）D3, 25-（OH）D deficiency in the recurrent infection group were significantly higher than those in the control group(all P＜0.05). The detection rate of vitamin A, 25-（OH）D3 and 25-（OH）D deficiency in the 1-3 years group were significantly higher than those in the ＜1 year group and ＞3 years group (all P＜0.05). There was no significant difference in the detection rate of vitamin E deficiency in children of different age groups (P＞0.05).  Conclusions The contents of vitamin A, vitamin D and vitamin E decreased significantly in children with recurrent respiratory tract infection. Appropriate supplement of related vitamins may reduce the incidence of respiratory tract infection in children.