2020 年第 7 期 第 15 卷

急性心肌梗死患者心型脂肪酸结合蛋白和高敏心肌肌钙蛋白T水平的变化及意义

The change and significance of heart-type fatty acid binding protein and high sensitive cardiac troponin T in patients with acute myocardial infarction

作者：邢宝宝1曹银芳1田丽丽2

英文作者：Xing Baobao1 Cao Yinfang1 Tian Lili2 

单位：1内蒙古自治区人民医院检验科，呼和浩特010010；2内蒙古自治区人民医院干部保健所四楼老年ICU，呼和浩特010010

英文单位：1Department of Laboratory Medicine Inner Mongolia People′s Hospital Hohhot 010010 China; 2ICU for the elderly on the fourth floor of Cadre Health Center Inner Mongolia People′s Hospital Hohhot 010010 China

关键词：急性心肌梗死；心型脂肪酸结合蛋白；高敏心肌肌钙蛋白；心电图

英文关键词：Acutemyocardialinfarction;Heart-typefattyacidbindingprotein;Highsensitivitycardiactroponin;Electrocardiogram

• 摘要：

• 目的探讨急性心肌梗死患者心型脂肪酸结合蛋白和高敏心肌肌钙蛋白T水平的变化及意义。方法选取2018年1—12月内蒙古自治区人民医院急诊科收治的急性心肌梗死患者126例，根据心电图是否伴有ST段抬高分为ST段抬高组（98例）和非ST段抬高组（28例）。另纳入本院同期100例健康志愿者作为对照组。分别检测受试者血清心型脂肪酸结合蛋白、高敏心肌肌钙蛋白T水平，分析心电图、心型脂肪酸结合蛋白、高敏心肌肌钙蛋白T水平联合检测在急性心肌梗死临床诊断中的价值。结果ST段抬高组和非ST段抬高组患者心型脂肪酸结合蛋白水平明显高于对照组［（10.1±1.6）、（7.0±1.3）μg/L比（2.8±1.0）μg/L］（t=39.16，P<0.01；t=18.04，P<0.01），高敏心肌肌钙蛋白T水平明显高于对照组［（1.293±0.136）、（0.048±0.011）μg/L比（0.008±0.001）μg/L］（t=94.49，P<0.01；t=36.20，P<0.01），差异均有统计学意义。ST段抬高组心型脂肪酸结合蛋白、高敏心肌肌钙蛋白T水平显著高于非ST段抬高组（t=9.64，P<0.01；t=48.26，P<0.01）。心型脂肪酸结合蛋白及高敏心肌肌钙蛋白T与心电图联合检测诊断急性心肌梗死的敏感度、准确率明显高于心电图单独检查（84.13%比19.84%、85.13%比35.71%），差异均有统计学意义（均P<0.05）。结论急性心肌梗死患者心型脂肪酸结合蛋白及高敏心肌肌钙蛋白T水平明显升高，二者与心电图联合检测诊断急性心肌梗死有较高的敏感度和准确率。

• ObjectiveTo investigate the change and significance of heart-type fatty acid binding protein and high sensitive cardiac troponin T in patients with acute myocardial infarction. Methods From January to December 2018, 126 patients with acute myocardial infarction admitted to the department of emergency， Inner Mongolia People′s Hospital were selected. The patients were divided into ST-segment elevation group(98 cases) and non ST-segment elevation group(28 cases) according to the results   of electrocardiogram. One hundred healthy volunteers were included as the control group during the same period. The level of serum heart-type fatty acid binding protein and high-sensitivity cardiac troponin T  of the three groups were detected respectively. The value of clinical diagnosis of combined detection of electrocardiogram, heart-type fatty acid binding protein and high-sensitivity cardiac troponin T in patients with acute myocardial infarction were analyzed. Results  The level of heart-type fatty acid binding protein in ST-segment elevation group and non ST-segment elevation group were significantly higher than that in the control group［（10.1±1.6）, （7.0 ±1.3）μg/L vs （2.8±1.0）μg/L］（t=39.16, P<0.01; t=18.04, P<0.01）; the level of high-sensitivity cardiac troponin T were significantly higher than that in the control group［（1.293±0.136），（0.048±0.011）μg/L vs （0.008±0.001）μg/L］（t=94.49, P<0.01; t=36.20, P<0.01）. The levels of heart-type fatty acid binding protein and high sensitive cardiac troponin T in ST-segment elevation group were significantly higher than those in non ST-segment elevation group（t=9.64, P<0.01; t=48.26, P<0.01）. The sensitivity and accuracy of combined detection of heart-type fatty acid binding protein, high-sensitivity cardiac troponin T and electrocardiogram in the diagnosis of acute myocardial infarction were significantly higher than those of electrocardiogram alone(84.13% vs 19.84%, 85.13% vs 35.71%, all P<0.05). Conclusions  The levels of heart-type fatty acid binding protein and high-sensitivity cardiac troponin T in patients with acute myocardial infarction are significantly high. The combined detection shows a high sensitivity and accuracy in the diagnosis of acute myocardial infarction. ='font-size:16px;font-family:"Calibri","sans-serif";mso-ascii-theme-font: minor-latin;mso-fareast-font-family:宋体;mso-fareast-theme-font:minor-fareast; mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language: ZH-CN;mso-bidi-language:AR-SA'>s Hospital, Hohhot 010010, China