2020 年第 1 期 第 15 卷

硝苯地平缓释片联合硫酸镁对妊娠期高血压患者肾功能及心脏血流动力学的影响

Effect of nifedipine sustained-release tablets combined with magnesium sulfate on renal function and cardiac hemodynamics in patients with pregnancy-induced hypertension

作者：任保红1付玉峰1孟庆勇1赵燕2陈小琳2

英文作者：

单位：1陕西省汉中市中心医院药剂科723000；2西安交通大学附属西安市中心医院肾病科710003

英文单位：

关键词：妊娠期高血压；硝苯地平缓释片；硫酸镁注射液；肾功能；心脏血流动力学

英文关键词：

• 摘要：

• 【摘要】目的    探讨硝苯地平缓释片联合硫酸镁对妊娠期高血压患者肾功能及心脏血流动力学的影响。方法    选择2017年3月至2019年3月陕西省汉中市中心医院收治的妊娠期高血压患者110例，采用随机数余数分组法分为联合组和单药组，各55例。单药组采用硫酸镁注射液治疗，联合组在单药组基础上联合硝苯地平缓释片治疗。比较2组治疗前后24 h尿肌酐量及尿蛋白量、阻力指数、脐动脉舒张压血流峰速比值(S/D)、血浆黏度、血细胞比容、收缩压、舒张压、同型半胱氨酸（Hcy）和C反应蛋白（CRP）水平。结果    治疗后，2组24 h尿肌酐量、24 h尿蛋白量、阻力指数、S/D、血浆黏度、血细胞比容、收缩压、舒张压和血清Hcy、CRP水平均明显低于治疗前，且联合组明显低于单药组［（7.0±1.6）mmol比（9.0±1.9）mmol、（1.02±0.22）g比（1.96±0.25）g、（0.24±0.05）比（0.43±0.06）、（1.6±0.3）比（2.0±0.4）、（2.1±0.4）mPa·s比（3.2±0.4）mPa·s、（35.7±2.6）%比（39.3±2.3）%、（112±7）mmHg（1 mmHg=0.133 kPa）比（129±7）mmHg、（84±6）mmHg比（95±6）mmHg、（10.5±1.6）μmol/L比（14.7±2.0）μmol/L、（1.5±0.4）mg/L比（2.0±0.5）mg/L］，差异均有统计学意义(均P＜0.05)。结论    硝苯地平缓释片联合硫酸镁能有效改善妊娠期高血压患者肾功能及心脏血流动力学，使血压恢复至正常范围。

• 【Abstract】Objective    To investigate the effect of nifedipine sustained-release tablets combined with magnesium sulfate on renal function and cardiac hemodynamics in patients with pregnancy-induced hypertension. Methods    A total of 110 cases of pregnancy-induced hypertension admitted to Hanzhong Central Hospital, Shaanxi Province were enrolled from March 2017 to March 2019. The patients were randomly divided into combination group and single drug group, with 55 cases in each group. The single drug group was treated with magnesium sulfate injection and the combination group was treated with nifedipine sustained-release tablets plus magnesium sulfate. Relevant indexes including 24 h urine creatinine and urinary protein, resistance index, umbilical artery diastolic peak velocity ratio(S/D), plasma viscosity, hematocrit, systolic blood pressure, diastolic blood pressure, serum homocysteine(Hcy) and C-reactive protein(CRP) were analyzed before and after treatment. Results    After treatment, 24 h urinary creatinine, 24 h urinary protein, resistance index, S/D, plasma viscosity, hematocrit, systolic blood pressure, diastolic blood pressure, serum Hcy and CRP levels significantly reduced in both groups; the indexes in the combionation group were significantly lower than those in the single drug group［（7.0±1.6）mmol vs （9.0±1.9）mmol, （1.02±0.22）g vs （1.96±0.25）g, （0.24±0.05） vs （0.43±0.06）, （1.6±0.3） vs （2.0±0.4）, （2.1±0.4）mPa·s vs （3.2±0.4）mPa·s, （35.7±2.6）% vs （39.3±2.3）%, （112±7）mmHg vs （129±7）mmHg, （84±6）mmHg vs （95±6）mmHg, （10.5±1.6）μmol/L vs （14.7±2.0）μmol/L, （1.5±0.4）mg/L vs （2.0±0.5）mg/L］(all P＜0.05). Conclusion    Nifedipine sustained-release tablets combined with magnesium sulfate can effectively improve renal function, cardiac hemodynamics and blood pressure in patients with pregnancy-induced hypertension.