2019 年第 11 期 第 14 卷

利托君对先兆早产流产妇女白细胞介素水平和外周血调节性T细胞表达及妊娠结局的影响

Effect of ritodrine on interleukin and regulatory T cell expressions in peripheral blood and pregnancy outcome in women with threatened abortion and preterm delivery    

作者：袁峰袁晓华陈晓鹏

英文作者：

单位：710068西安，陕西省人民医院产科

英文单位：

关键词：早产流产；利托君；白细胞介素；外周血调节性T细胞

英文关键词：

• 摘要：

• 【摘要】目的    探讨利托君对先兆早产流产妇女白细胞介素（IL）水平和外周血调节性T细胞（Treg）表达及妊娠结局的影响。方法    选取2016年8月至2017年8月陕西省人民医院收治的92例先兆早产流产孕妇作为研究对象。按照随机数字表法分为对照组和观察组，各46例。对照组患者给予硫酸镁注射液治疗；观察组患者给予利托君注射液及利托君片治疗。比较2组患者IL-8、IL-10以及外周血Treg表达水平，观察2组患者妊娠结局。结果    治疗前2组患者IL-8、IL-10及Treg表达水平差异均无统计学意义（均P＞0.05）。治疗后观察组IL-8水平明显低于对照组，IL-10水平、Treg占CD+4T细胞百分比、Treg占总淋巴细胞百分比明显高于对照组［（42±6）ng/L比（59±6）ng/L、（225±36）ng/L比（173±31）ng/L、（5.1±0.6）%比（4.1±0.5）%、（7.2±0.7）%比（5.5±0.6）%］，差异均有统计学意义（均P＜0.05）。观察组成功继续妊娠率高于对照组［80.4%（37/46）比60.9%（28/46）］，差异有统计学意义（χ2=9.225，P=0.030）。结论    利托君治疗早产流产效果较好，可有效调节孕妇IL-8、IL-10和外周血Treg细胞表达水平，改善妊娠结局。

• 【Abstract】Objective    To investigate the effect of ritodrine on interleukin(IL) and regulatory T cell(Treg) expressions in peripheral blood and pregnancy outcome in women with threatened abortion and preterm delivery. Methods    Ninety-two pregnant women with threatened abortion and preterm delivery admitted to Shaanxi Provincial People′s Hospital from August 2016 to August 2017 were randomly divided into control group and observation group, with 46 cases in each group. The control group was treated with magnesium sulfate injection. The observation group was treated with ritodrine injection and ritodrine tablets. Expression levels of IL-8, IL-10 and Treg in peripheral blood were detected. Pregnancy outcome was observed. Results    There were no significant differences of IL-8, IL-10 and Treg expressions between groups before treatment(all P>0.05). After treatment, IL-8 level in observation group was significantly lower while IL-10 level, the percentage of Treg to CD+4 T cells and the percentage of Treg to total lymphocytes were significantly higher than those in control group［（42±6）ng/L vs （59±6）ng/L, （225±36）ng/L vs （173±31）ng/L, （5.1±0.6）% vs （4.1±0.5）%, （7.2±0.7）% vs （5.5±0.6）%］(all P<0.05). Successful pregnancy rate in observation group was significantly higher than that in control group［80.4%(37/46) vs 60.9%(28/46)］(χ2=9.225, P=0.030). Conclusion    Ritodrine can effectively regulate IL-8, IL-10 and Treg expressions and improve the pregnancy outcome of threatened abortion and preterm delivery.