2019 年第 9 期 第 14 卷

益气复生方联合XELOX方案治疗脾气虚型胃癌的效果及对患者生活质量的影响

Effect of Yiqi Fusheng prescription combined with XELOX chemotherapy on gastric carcinoma with spleen-qi deficiency and quality of life 

作者：何娜娜热娜古丽·艾则孜陈音

英文作者：

单位：830000乌鲁木齐，新疆医科大学附属中医医院肿瘤一科

英文单位：

关键词：脾气虚型胃癌；益气复生方；XELOX方案；免疫力；生活质量

英文关键词：

• 摘要：

• 【摘要】目的    探讨益气复生方联合XELOX方案治疗脾气虚型胃癌的效果及对患者生活质量的影响。方法    选取2014年3月至2016年4月新疆医科大学附属中医医院收治的脾气虚型胃癌患者110例，依据随机数字表法分为对照组和观察组，各55例。对照组采用XELOX方案治疗，21 d为1个疗程，持续4个疗程；观察组采用益气复生方联合XELOX方案治疗，21 d为1个疗程，持续4个疗程。比较2组患者治疗效果、不良反应发生情况、T淋巴细胞亚群水平和生活质量变化情况。结果    治疗后，观察组患者治疗有效率明显高于对照组［87.3%(48/55)比56.4%(31/55)］，差异有统计学意义（P＜0.05）。治疗过程中，观察组患者的消化道反应、腹泻、骨髓抑制、手足综合征发生率均明显低于对照组［43.6%(24/55)比65.5%(36/55)、27.3%(15/55)比47.3%(26/55)、23.6%(13/55)比40.0%(22/55)、41.8%(23/55)比72.7%(40/55)］，差异均有统计学意义（均P＜0.05）。治疗后，观察组患者CD+3、CD+4、CD+8、CD+4/CD+8水平和生活质量各项评分均明显高于对照组，差异均有统计学意义（均P＜0.05）。结论    益气复生方联合XELOX方案治疗脾气虚型胃癌效果较好，可以有效减少患者治疗过程中的不良反应，增强机体免疫力，提高生活质量。

• 【Abstract】Objective    To explore the effect of Yiqi Fusheng prescription combined with XELOX chemotherapy on gastric carcinoma with spleen-qi deficiency and quality of life. Methods    Totally 110 patients with spleen-qi deficiency gastric carcinoma admitted to Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University from March 2014 to April 2016 were enrolled. The patients were randomly divided into control group and observation group, with 55 cases in each group. The control group was treated with XELOX chemotherapy for 4 courses; the observation group was treated with Yiqi Fusheng prescription combined with XELOX therapy; 1 course was 21 d. Both groups were treated for 4 courses. Therapeutic effect, adverse reactions, T lymphocyte subsets and quality of life were analyzed. Results    After treatment, the clinical effective rate in observation group was significantly higher than that in control group［87.3%(48/55) vs 56.4%(31/55)］(P＜0.05). Incidences of gastrointestinal reaction, diarrhea, bone marrow suppression and hand-foot syndrome in observation group were significantly lower than those in control group［43.6%(24/55) vs 65.5%(36/55), 27.3%(15/55) vs 47.3%(26/55), 23.6%(13/55) vs 40.0%(22/55), 41.8%(23/55) vs 72.7%(40/55)］(all P＜0.05). After treatment, levels of CD+3, CD+4, CD+8, CD+4/CD+8 ratio and scores of life quality in observation group were significantly higher than those in control group(all P＜0.05). Conclusion    Yiqi Fusheng prescription combined with XELOX chemotherapy treating spleen-qi deficiency gastric carcinoma can effectively improve the therapeutic effect, reduce adverse events, enhance body immunity and improve quality of life.