2019 年第 4 期 第 14 卷

新靶位基因RET在非小细胞肺癌中的研究进展

Research progress of new target gene RET in non-small cell lung cancerLiu Caixia, Jia Jinhu, Jing Lijun, Huo Tingting

作者：刘彩霞贾金虎井丽君霍婷婷

英文作者：

单位：730050兰州，解放军联勤保障部队第九四○医院保健一部（刘彩霞、井丽君、霍婷婷）；735000甘肃省酒泉市人民医院呼吸内科（贾金虎）

英文单位：

关键词：非小细胞肺癌；RET基因

英文关键词：

• 摘要：

• 【摘要】肺癌是目前所有恶性肿瘤中发病率、病死率最高的肿瘤之一，因早期临床表现不典型，多数患者确诊时已处于晚期。近年来，因基因靶向治疗的问世及精准医学的发展，传统一线化疗方案因不良反应较多而逐渐被基因靶向治疗所取代，但基因靶向治疗有效的前提是特定基因的突变。RET基因是最新研究发现的与非小细胞肺癌发病关系较为密切的少见突变基因，在非小细胞肺癌的诊断、治疗策略选择、预后等方面有着重要的临床意义。因此，深入研究RET基因在非小细胞肺癌诊疗中的具体作用机制，对晚期非小细胞肺癌少见基因突变患者的靶向精准诊治具有重要指导意义。

• 【Abstract】Lung cancer is one of the most malignant tumors with the highest morbidity and mortality； most of the patients are diagnosed in the advanced stage as the early clinical manifestations are not typical. In recent years, gene targeting therapy and precision medicine have made great development and taken the place of traditional first-line chemotherapy which has more adverse reactions. The effective premise of gene targeting therapy is the mutation of specific genes. RET gene is a new target closely related to the pathogenesis of non-small cell lung cancer; it shows important clinical significances in the diagnosis, treatment and prognosis of the disease. It is necessary to explore the specific mechanisms of RET gene in non-small cell lung cancer to provide guidance for the precise diagnosis and treatment in non-small cell lung cancer patients at advanced stage with rare gene mutation.