2018 年第 6 期 第 13 卷

2型糖尿病患者合并动脉粥样硬化危险因素分析

Risk factors of atherosclerosis in patients with type 2 diabetes

作者：石维陈雷卜瑞芳

英文作者：

单位：214000南京医科大学附属无锡市人民医院内分泌科（石维、卜瑞芳），超声科（陈雷）

英文单位：

关键词：2型糖尿病；动脉粥样硬化；危险因素

英文关键词：

• 摘要：

• 【摘要】目的    探讨2型糖尿病患者合并动脉粥样硬化的危险因素。方法    收集2014年8月至2015年8月南京医科大学附属无锡市人民医院收治的2型糖尿病患者200例的病历资料，按照是否合并动脉粥样硬化分为动脉粥样硬化组（126例）和非动脉粥样硬化组（74例），比较2组基本资料与生化指标，分析2型糖尿病患者合并动脉粥样硬化的危险因素。结果    动脉粥样硬化组年龄、病程、三酰甘油、低密度脂蛋白胆固醇（LDL-C）水平均明显高于非动脉粥样硬化组［（56±9）岁比（53±8）岁、（6±5）年比（5±4）年、（3.1±1.1）mmol/L比（2.7±0.8）mmol/L、（2.7±0.8）mmol/L比（2.2±0.7）mmol/L］，而高密度脂蛋白胆固醇（HDL-C）水平明显低于非动脉粥样硬化组［（0.94±0.19）mmol/L比（1.01±0.30）mmol/L］，差异均有统计学意义（均P＜0.05）。Logistic回归分析结果显示，高龄、长病程、高三酰甘油以及LDL-C水平是2型糖尿病患者合并动脉粥样硬化的独立危险因素，而高HDL-C水平是其保护因素（均P＜0.05）。结论    高龄、长病程、高三酰甘油和LDL-C、低HDL-C均会促进2型糖尿病患者动脉粥样硬化的发生。

• 【Abstract】Objective    To analyze the risk factors of atherosclerosis in patients with type 2 diabetes. Methods    Clinical data of 200 patients with type 2 diabetes in Wuxi People′s Hospital Affiliated to Nanjing Medical University from August 2014 to August 2015 were reviewed; the patients were divided into arteriosclerosis group（n＝126） and non-arteriosclerosis group（n＝74）. General information and biochemical indexes were analyzed. Results    Age, course of diabetes, levels of triacylglycerol（TG） and low-density lipoprotein cholesterol（LDL-C） in atherosclerosis group were significantly higher than those in non-arteriosclerosis group［（56±9）years vs （53±8）years, （6±5）years vs （5±4）years, （3.1±1.1）mmol/L vs （2.7±0.8）mmol/L, （2.7±0.8）mmol/L vs （2.2±0.7）mmol/L］; high-density lipoprotein cholesterol (HDL-C) level in atherosclerosis group was significantly lower than that in non-arteriosclerosis group［（0.94±0.19）mmol/L vs （1.01±0.30）mmol/L］（all P＜0.05）. Logistic regression analysis showed that advanced age, long course of diabetes, high levels of TG and LDL-C were independent risk factors of arteriosclerosis; high level of HDL-C was a protective factor of arteriosclerosis(P＜0.05). Conclusion    Age, course of disease, levels of TG, HDL-C and LDL-C are closely related to the occurrence of arteriosclerosis in patients with type 2 diabetes.