2025 年第 2 期 第 20 卷

早发冠心病合并抑郁的现状及研究进展

Current status and research progress of premature coronary atherosclerotic heart disease combined with depression

作者：孙宇阳刘晓丽韩红亚李孟晨刘宇

英文作者：Sun Yuyang， Liu Xiaoli， Han Hongya， Li Mengchen， Liu Yu

单位：首都医科大学附属北京安贞医院老年心血管病中心，北京100029

英文单位：Geriatric Cardiovascular Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：早发冠心病；抑郁；研究进展；发病机制

英文关键词：Prematurecoronaryatheroscleroticheartdisease;Depression;Researchprogress;Mechanism

• 摘要：

• 冠心病（冠状动脉粥样硬化性心脏病）目前仍是影响全球健康负担的主要疾病之一。随着社会快速发展和生活节奏加快，在青年人群中，冠心病的发病率呈上升趋势。抑郁与冠心病的双向作用，对冠心病的发生、发展以及预后都产生了一定的影响。本文通过对国内外冠心病抑郁患者的现状及研究进展进行综述，尤其是针对早发冠心病人群，总结其流行病学、发病机制、治疗方法，以期为冠心病合并抑郁患者的临床诊治提供依据。

• Coronary atherosclerotic heart disease is still one of the major diseases affecting the global health burden. With the rapid development of society and the acceleration of the pace of life, the incidence of coronary atherosclerotic heart disease is on the rise in young people. The bidirectional effect of depression and coronary atherosclerotic heart disease has a certain impact on the occurrence, development and prognosis of coronary heart disease.This article reviews the current status and research progress of depression in patients with coronary atherosclerotic heart disease at home and abroad, especially for patients with premature coronary atherosclerotic heart disease, and summarizes its epidemiology, pathogenesis and treatment methods, in order to provide a basis for the clinical diagnosis and treatment of patients with coronary atherosclerotic heart disease complicated with depression.