2025 年第 2 期 第 20 卷

疏肝和胃方联合莫沙必利对肝胃不和型功能性消化不良患者胃肠激素和炎症因子水平及生活质量的影响

Effects of Shugan Hewei decoction combined with mosapride on the levels of gastrointestinal hormones and inflammatory factors and quality of life in patients with functional dyspepsia of incoordination between the liver and stomach type

作者：祁正亮1田曼2刘晓3

英文作者：Qi Zhengliang1 Tian Man2 Liu Xiao3

单位：1湖北省中医院湖北中医药大学附属医院湖北省中医药研究院老年病科，武汉430061；2湖北省中医院湖北中医药大学附属医院湖北省中医药研究院内分泌科，武汉430061；3湖北中医药大学，武汉430061

英文单位：1Department of Geriatrics Hubei Provincial Hospital of Traditional Chinese Medicine Affiliated Hospital of Hubei University of Chinese Medicine Hubei Provincial Institute of Traditional Chinese Medicine Wuhan 430061 China; 2Department of Endocrinology Hubei Provincial Hospital of Traditional Chinese Medicine Affiliated Hospital of Hubei University of Chinese Medicine Hubei Provincial Institute of Traditional Chinese Medicine Wuhan 430061 China; 3Hubei University of Chinese Medicine Wuhan 430061 China

关键词：功能性消化不良；疏肝和胃方；莫沙必利；胃肠激素；炎症因子；生活质量

英文关键词：Functionaldyspepsia;ShuganHeweidecoction;Mosapride;Gastrointestinalhormones;Inflammatoryfactors;Qualityoflife

• 摘要：

• 目的 探讨疏肝和胃方联合莫沙必利对肝胃不和型功能性消化不良（FD）患者胃肠激素和炎症因子水平及生活质量的影响。方法 选取2021年10月至2023年10月在湖北省中医院就诊的肝胃不和型FD患者120例，完全随机分为西药组和中西药组，各60例。西药组口服莫沙必利治疗，中西药组在西药组基础上服用疏肝和胃方治疗，2组患者均连续治疗1个月。比较2组患者临床疗效、胃肠激素、生长抑素、胃蛋白酶原（PG）、炎症因子水平、中医证候积分、生活质量和焦虑、抑郁评分。结果 治疗后中西药组总有效率显著高于西药组［93.3%（56/60）比78.3%（47/60）］，差异有统计学意义（P=0.018）。治疗后2组患者胃动素、胃泌素及PGⅠ水平均显著高于治疗前且中西药组均显著高于西药组；生长抑素、PGⅡ水平及胸胁胀痛、嗳气、脘腹痞满、心烦评分、白细胞介素6、肿瘤坏死因子α、C反应蛋白水平均显著低于治疗前且中西药组均显著低于西药组（均P＜0.05）。治疗后2组患者FD生存质量量表评分显著高于治疗前且中西药组显著高于西药组，而焦虑自评量表和抑郁自评量表评分均显著低于治疗前且中西药组均显著低于西药组（均P<0.05）。结论 疏肝和胃方联合莫沙必利治疗肝胃不和型FD患者可以提高临床效果，缓解临床症状，调节患者的胃肠激素和PG水平，降低机体的炎症水平，提高生活质量，缓解抑郁和焦虑状况。

• Objective To investigate the effects of Shugan Hewei decoction combined with mosapride on the levels of gastrointestinal hormones and inflammatory factors and quality of life in patients with functional dyspepsia (FD) of incoordination between the liver and stomach type. Methods A total of 120 FD patients with liver-stomach dif-ferment who were treated in Hubei Provincial Hospital of Traditional Chinese Medicine from October 2021 to October 2023 were selected. They were randomly divided into western medicine group and traditional Chinese and western medicine group, with 60 cases in each group. The western medicine group was treated with mosapride, and the Chinese and western medicine group was treated with Shugan Hewei decoction on the basis of the western medicine group. The patients in both groups were treated for 1 month. The clinical efficacy, gastrointestinal hormone, somatostatin, pepsinogen (PG), inflammatory factor levels, traditional Chinese medicine syndrome scores, quality of life, anxiety and depression scores were compared between the two groups. Results After treatment, the total effective rate of the Chinese and western medicine group was significantly higher than that of the western medicine group［93.3%(56/60) vs 78.3%(47/60)］(P=0.018). After treatment, the levels of motilin, gastrin and PGⅠ in the two groups were significantly higher than those before treatment, and the levels in the Chinese and western medicine group were significantly higher than those in the western medicine group; The levels of somatostatin and PGⅡ, chest and flank pain, belching, abdominal fullness, upset scores, interleukin-6, tumor necrosis factor-α and C-reactive protein in the Chinese and western medicine group were significantly lower than those before treatment, and those in the Chinese and western medicine group were significantly lower than those in the western medicine group(all P<0.05). After treatment, the FD quality of life scale scores of the two groups were significantly higher than those before treatment, and that in the Chinese and western medication group was significantly higher than that in the western medication group, while the self-rating anxiety scale and self-rating depression scale scores were significantly lower than those before treatment, and those in the Chinese and western medication group was significantly lower than those in the western medication group(all P<0.05). Conclusion Shugan Hewei decoction combined with mosapride in the treatment of patients with FD of incoordination between the liver and stomach type can improve the clinical effect, relieve clinical symptoms, regulate the levels of gastrointestinal hormones and PG, reduce the level of inflammation, improve the quality of life, and relieve depression and anxiety.