2025 年第 1 期 第 20 卷

原发性硬化性胆管炎合并炎症性肠病的研究进展

Research progress on primary sclerosing cholangitis complicated with inflammatory bowel disease

作者：吴朴仙1 林婧1 任鹏程1 王红霞1 王祥2

英文作者：Wu Puxian1 Lin Jing1 Ren Pengcheng1 Wang Hongxia1 Wang Xiang2

单位：1兰州大学第二临床医学院，兰州730000；2兰州大学第二医院消化科，兰州730000

英文单位：1The Second Clinical Medical School Lanzhou University Lanzhou 730000 China； 2Department of Gastroenterology the Second Hospital Lanzhou University Lanzhou 730000 China

关键词：原发性硬化性胆管炎；  炎症性肠病；  发病机制；  临床特征；  肿瘤

英文关键词：Primarysclerosingcholangitis；  Inflammatoryboweldisease;  Pathogenesis;  Clinicalphenotype;  Tumor

• 摘要：

• 原发性硬化性胆管炎（PSC）是一种胆道的慢性胆汁淤积性疾病，在病程中常合并炎症性肠病(IBD)。PSC与IBD共存时表现出不同于独立疾病的临床表型、疾病转归和肿瘤风险，影响疾病的治疗和管理。本文就PSC合并IBD的发病机制、病程间的相互影响以及相关恶性肿瘤的风险及监测进行综述，以期增强临床医师对于疾病的认识，并为PSC合并IBD的临床研究和诊疗提供新的思路。

• Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease of the biliary tract, which is often accompanied by inflammatory bowel disease (IBD). PSC coexisting with IBD shows different clinical phenotypes, disease outcome and tumor risk from independent diseases, which affects the treatment and management of the disease. This article reviews the pathogenesis of PSC complicated with IBD, the interaction between the course of disease, and the risk and monitoring of related malignant tumors, in order to enhance clinicians′ understanding of the disease and provide new ideas for the clinical research and diagnosis and treatment of PSC complicated with IBD.