2024 年第 12 期 第 0 卷

细胞代谢对类风湿关节炎发病和治疗影响的研究进展

Research progress of cellular metabolism in the pathogenesis and treatment of rheumatoid arthritis

作者：张瑞1张莉2毛婧1李文花1张宪萌1沈海丽2

英文作者：Zhang Rui1 Zhang Li2 Mao Jing1 Li Wenhua1 Zhang Xianmeng1 Shen Haili2

单位：1兰州大学第二临床医学院，兰州730030；2兰州大学第二医院风湿免疫科，兰州730030

英文单位：1The Second Clinical Medical School Lanzhou University Lanzhou 730030 China; 2Department of Rheumatology and Immunology the Second Hospital Lanzhou University Lanzhou 730030 China

关键词：类风湿关节炎；免疫细胞；代谢紊乱；靶向治疗

英文关键词：Rheumatoidarthritis;Immunecells;Metabolicdisorders;Targetedtherapy

• 摘要：

• 类风湿关节炎（RA）是一种慢性全身免疫性疾病，其主要特征包括滑膜炎症反应和关节渐进破坏。细胞代谢紊乱与RA的病理密切相关，在炎症部位，由于能量源受限制，炎症细胞通过代谢适应以执行其稳态功能，这种变化不仅影响了细胞的功能，还加剧了炎症反应。免疫细胞和基质细胞的代谢异常被认为是RA慢性炎症的重要驱动因素。乳酸等代谢产物在调节免疫细胞功能中起着关键作用。本文就糖酵解、线粒体代谢、脂质和氨基酸代谢在RA中的重要作用和代谢靶向治疗的现状进行综述，以期为RA的治疗提供新的思路。

• Rheumatoid arthritis (RA) is a chronic systemic immune disease characterized by synovial inflammation and progressive joint destruction. Disorders of cell metabolism are closely related to the pathology of RA. At the site of inflammation, due to the limitation of energy sources, inflammatory cells adapt to perform their homeostatic functions through metabolism. Metabolic abnormalities in immune cells and stromal cells are considered to be important drivers of chronic inflammation in RA. Metabolites such as lactate play a key role in regulating immune cell function. This article reviews the important role of glycolysis, mitochondrial metabolism, lipid and amino acid metabolism in RA and the current status of metabolic-targeted therapy, in order to provide new ideas for the treatment of RA.