2024 年第 12 期 第 0 卷

脑小血管病与血清炎症生物标志物关系及潜在治疗靶点的研究进展

Research progress on the relationship between cerebral small vessel disease and serum inflammatory biomarkers and potential therapeutic targets

作者：罗文倩韦婷刘彬李衍滨

英文作者：Luo Wenqian Wei Ting Liu Bin Li Yanbin

单位：山东第一医科大学第一附属医院（山东省千佛山医院）神经内科，济南250014

英文单位：Department of Neurology the First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250014 China

关键词：脑小血管疾病；炎症；生物标志物；治疗靶点

英文关键词：Cerebralsmallvesseldisease;Inflammation;Biomarkers;Therapeutictarget

• 摘要：

• 脑小血管病（CSVD）逐渐成为威胁人们健康及生活质量的重要疾病，主要引起人们的认知障碍、运动障碍、情感障碍、大小便失禁等症状，致残及致死率高。该病在老年人群中高发，与脑卒中的发生和复发、认知功能障碍、心理障碍有关。虽然目前对CSVD的生理病理过程尚不明确，但有研究证实炎症反应在CSVD的发病机制中有着至关重要的作用。因此通过探索CSVD的生理病理，以期寻找到合适的血清炎症生物标志物及潜在治疗靶点，进而能对CSVD的进展及预后进行早期预警。因此，本文就CSVD血清炎症生物标志物相关研究进展及潜在治疗靶点进行综述。

• Cerebral small vessel disease (CSVD) has gradually become an important disease that threatens people′s health and quality of life, mainly causing cognitive impairment, movement disorders, emotional disorders, urinary and fecal incontinence and other symptoms, with high disability and mortality. It has a high incidence in the elderly population and is related to the occurrence and recurrence of stroke, cognitive dysfunction and psychological disorders. Although the physiological and pathological process of CSVD is still unclear, some studies have confirmed that inflammatory response plays a crucial role in the pathogenesis of CSVD. Therefore, by exploring the physiology and pathology of CSVD, we hope to find appropriate serum inflammatory biomarkers and potential therapeutic targets, so as to provide early warning for the progression and prognosis of CSVD. Therefore, this article reviews the research progress and potential therapeutic targets of serum inflammatory biomarkers in CSVD.