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2024 年第 12 期 第 0 卷

清开灵口服液治疗儿童手足口病的临床研究

Clinical study of Qingkailing oral liquid in the treatment of hand-foot-mouth disease in children

作者:马毛毛1高慧2李婵1

英文作者:Ma Maomao1 Gao Hui2 Li Chan1

单位:1延安大学第二附属医院(陕西省榆林市第一医院)儿科,榆林719000;2西安交通大学第一附属医院榆林医院药剂科,榆林719000

英文单位:1Department of Pediatrics the Second Affiliated Hospital of Yan′an University (the First Hospital of Yulin Shaanxi Province) Yulin 719000 China; 2Department of Pharmacy Yulin Hospital the First Affiliated Hospital of Xi′an Jiaotong University Yulin 719000 China

关键词:手足口病;清开灵口服液;人干扰素α2b喷雾剂

英文关键词:Hand-foot-mouthdisease;Qingkailingoralliquid;Humaninterferonα2bspray

  • 摘要:
  • 目的 探讨清开灵口服液联合人干扰素α2b喷雾剂治疗儿童手足口病的效果。方法 选取2021年12月至2023年12月陕西省榆林市第一医院收治的手足口病轻症患儿98例。根据治疗方法不同将患儿分为对照组和观察组,各49例。对照组采用人干扰素α2b喷雾剂治疗,观察组采用清开灵口服液联合人干扰素α2b喷雾剂治疗。比较2组的治疗效果、临床症状恢复时间、血清指标、T淋巴细胞亚群、不良反应发生情况。结果 观察组治疗总有效率高于对照组[95.9%(47/49)比83.7%(41/49)],差异有统计学意义(χ2=4.009,P=0.045)。观察组体温恢复正常时间、皮疹及疱疹消退时间均短于对照组,差异均有统计学意义(均P<0.05)。治疗后,2组C反应蛋白、白细胞介素17、肿瘤坏死因子α水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(均P<0.05)。治疗后,2组CD+3、CD+4、CD+4/CD+8比值水平均高于治疗前,且观察组均高于对照组,差异均有统计学意义(均P<0.05)。2组均未出现寒战、胃肠道反应、头痛等不良反应。结论 清开灵口服液联合人干扰素α2b喷雾剂治疗儿童手足口病可获得较为满意的效果,能有效改善机体炎症情况以及T淋巴细胞亚群的表达,且安全性较高。

  • Objective To investigate the effect of Qingkailing oral liquid combined with human interferon α2b spray in the treatment of hand-foot-mouth disease (HFMD) in children. Methods A total of 98 children with mild HFMD admitted to the First Hospital of Yulin, Shaanxi Province from December 2021 to December 2023 were selected. According to different treatment methods, the children were divided into control group and observation group, with 49 cases in each group. The control group was treated with human interferon α2b spray, and the observation group was treated with Qingkailing oral liquid combined with human interferon α2b spray. The therapeutic effect, recovery time of clinical symptoms, serum indexes, T lymphocyte subsets, and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group [95.9%(47/49) vs 83.7%(41/49)](χ2=4.009, P=0.045). The time for body temperature recovery, rash and herpes regression time in the observation group were shorter than those in the control group (both P<0.05). After treatment, the levels of C-reactive protein, interleukin-17 and tumor necrosis factor α in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (all P<0.05). After treatment, the levels of CD+3, CD+4 and CD+4/CD+8 ratio in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group (all P<0.05). There were no adverse reactions such as shivering, gastrointestinal reactions, and headache in the two groups. Conclusion Qingkailing oral liquid combined with human interferon α2b spray can achieve satisfactory effect in the treatment of children with HFMD, which can effectively improve the body′s inflammation and the expression of T lymphocyte subsets, and has high safety.

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