2024 年第 12 期 第 0 卷

益肺健脾颗粒联合多索茶碱治疗肺脾气虚型慢性支气管炎的临床效果观察

Observation on the clinical effect of Yifei Jianpi granule combined with doxofylline in the treatment of chronic bronchitis of lung spleen Qi deficiency type

作者：吴刚徐静李磊

英文作者：Wu Gang Xu Jing Li Lei

单位：南京中医药大学附属医院江苏省中医院呼吸与危重症医学科，南京210029

英文单位：Department of Respiratory and Critical Care Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029 China

关键词：慢性支气管炎；多索茶碱；益肺健脾颗粒；临床效果；中医证候；炎症因子；免疫功能

英文关键词：Chronicbronchitis;Doxofylline;YifeiJianpigranule;Clinicaleffect;TraditionalChinesemedicinesyndrome;Inflammatoryfactors;Immunefunction

• 摘要：

• 目的 观察益肺健脾颗粒联合多索茶碱治疗肺脾气虚型慢性支气管炎的临床效果。方法 回顾性收集南京中医药大学附属医院2021年1月至2023年10月收治的118例肺脾气虚型慢性支气管炎患者的临床资料进行分析，根据治疗方案不同分为观察组（59例）与对照组（59例）。对照组在基础干预基础上采用多索茶碱片治疗，观察组在对照组基础上增加益肺健脾颗粒治疗。比较2组的临床疗效、中医证候积分、炎症因子、免疫功能指标水平、治疗安全性。结果 观察组总有效率高于对照组［91.5%（54/59）比78.0%（46/59）］（P=0.041）。治疗后2组各项中医证候积分、白细胞介素17A、CXC趋化因子配体9、单核细胞趋化蛋白4水平均低于治疗前且观察组均低于对照组(均P<0.05)。治疗后2组CD+3、CD+4、CD+4/CD+8比值均高于治疗前且观察组均高于对照组，CD+8均低于治疗前且观察组低于对照组(均P<0.05)。2组不良反应总发生率差异无统计学意义（P=0.542）。结论 益肺健脾颗粒联合多索茶碱治疗肺脾气虚型慢性支气管炎的临床效果显著，可减轻患者主要中医证候，降低炎症因子水平，改善患者免疫功能，安全性良好。

• Objective To observe the clinical effect of Yifei Jianpi granule combined with doxofylline in the treatment of chronic bronchitis of lung spleen Qi deficiency type. Methods The clinical data of 118 patients with chronic bronchitis of lung spleen Qi deficiency type admitted to the Affiliated Hospital of Nanjing University of Chinese Medicine from January 2021 to October 2023 were retrospectively collected and analyzed. According to different treatment regimens, they were divided into observation group (59 cases) and control group (59 cases). The control group was treated with doxofylline tablets on the basis of basic intervention, and the observation group was treated with Yifei Jianpi granules on the basis of the control group. The clinical efficacy, traditional Chinese medicine syndrome score, inflammatory factors, immune function index levels, and treatment safety were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group ［91.5%(54/59) vs 78.0%(46/59)］(P=0.041). After treatment, the traditional Chinese medicine syndrome scores, levels of interleukin-17A, CXC chemokine ligand 9 and monocyte chemoattractant protein 4 in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (all P<0.05). After treatment, the CD+3, CD+4, and CD+4/CD+8 ratios in both groups were higher than those before treatment, and those in observation group were higher than those in control group; CD+8 was lower than that before treatment, and that in observation group was lower than that in control group (all P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P=0.542). Conclusion Yifei Jianpi granule combined with doxofylline has significant clinical effect in the treatment of chronic bronchitis of lung spleen Qi deficiency type, which can reduce the main traditional Chinese medicine syndromes of patients, reduce the levels of inflammatory factors, improve the immune function of patients, and has good safety.