2024 年第 12 期 第 0 卷

养心止痛颗粒治疗气虚血瘀证慢性稳定型心绞痛的临床效果及对患者血脂和炎症因子水平的影响观察

Observations on the clinical effect of Yangxin Zhitong granule in the treatment of chronic stable angina pectoris with Qi deficiency and blood stasis syndrome and its effect on blood lipid and inflammatory factor levels of patients

作者：赵鑫1孙静2葛媛2王贺2周亚滨2

英文作者：Zhao Xin1 Sun Jing2 Ge Yuan2 Wang He2 Zhou Yabin2

单位：1黑龙江中医药大学研究生院，哈尔滨150040；2黑龙江中医药大学附属第一医院心血管病二科，哈尔滨150040

英文单位：1Graduate School Heilongjiang University of Chinese Medicine Harbin 150040 China; 2the Second Department of Cardiovascular Disease First Affiliated Hospital Heilongjiang University of Chinese Medicine Harbin 150040 China

关键词：稳定型心绞痛；养心止痛颗粒；气虚血瘀证；炎症因子

英文关键词：Stableanginapectoris;YangxinZhitonggranule;Qideficiencyandbloodstasissyndrome;Inflammatoryfactors

• 摘要：

• 目的 观察养心止痛颗粒治疗气虚血瘀证慢性稳定型心绞痛的临床效果及对患者血脂和炎症因子水平的影响。方法 选取2021年6月至2024年6月于黑龙江中医药大学附属第一医院门诊就诊的气虚血瘀证慢性稳定型心绞痛患者共130例为研究对象，按随机数字表法分为观察组与对照组，各65例。对照组予以西医标准化治疗，观察组在对照组基础上加予养心止痛颗粒治疗，2组均治疗4周。比较2组中医证候积分及疗效、心绞痛症状积分及疗效以及血脂、炎症指标等的变化情况。结果 观察组中医证候疗效总有效率高于对照组（P<0.05）。治疗后观察组中医证候总积分明显低于对照组（P<0.05）。治疗后，2组患者心绞痛发作频率、每次疼痛持续时间、心绞痛症状总积分均低于/短于治疗前且观察组低于/短于对照组（均P<0.05）。观察组心绞痛疗效总有效率高于对照组［77.8%（49/63）比62.3%（38/61）］（χ2=8.094，P=0.017）。观察组心电图疗效总有效率高于对照组（P<0.05）。治疗后，观察组总胆固醇、甘油三酯、低密度脂蛋白胆固醇及高敏C反应蛋白、脂蛋白相关磷脂酶A2水平均低于对照组，高密度脂蛋白胆固醇水平高于对照组（均P<0.05）。2组治疗前后血尿常规、肝肾功能等安全性指标未见明显异常。结论 养心止痛颗粒可显著提高气虚血瘀证慢性稳定型心绞痛患者的临床总有效率，有效改善患者症状，发挥降脂抗炎作用，提高生存质量。

• Objective To observe the clinical effect of Yangxin Zhitong granule in the treatment of chronic stable angina pectoris with Qi deficiency and blood stasis syndrome and its effect on blood lipid and inflammatory factors.MethodsA total of 130 patients with chronic stable angina pectoris of Qi deficiency and blood stasis syndrome in the First Affiliated Hospital, Heilongjiang University of Chinese Medicine from June 2021 to June 2024 were selected as the research objects, and they were divided into observation group and control group according to the random number table method, with 65 cases in each group. The control group was treated with standardized western medicine, and the observation group was treated with Yangxin Zhitong granule on the basis of the control group. Both groups were treated for 4 weeks.The changes of traditional Chinese medicine syndrome score and curative effect, angina symptom score and curative effect, blood lipid and inflammatory index were compared between the two groups. Results The total effective rate of TCM syndrome in the observation group was higher than that in the control group (P<0.05). After treatment, the total score of TCM syndrome in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the frequency of angina attack, the duration of each pain, and the total score of angina symptoms in the two groups were lower/shorter than those before treatment, and the observation group was lower/shorter than the control group (all P<0.05). The total effective rate of angina pectoris in the observation group was higher than that in the control group ［77.8%(49/63) vs 62.3%(38/61)］(χ2=8.094, P=0.017). The total effective rate of electrocardiogram treatment in the observation group was higher than that in the control group (P<0.05). After treatment, the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein and lipoprotein associated phospholipase A2 in the observation group were lower than those in the control group, and the level of high-density lipoprotein cholesterol was higher than that in the control group (all P<0.05). There were no significant abnormalities in blood and urine routine, liver and kidney function before and after treatment in the two groups. Conclusion Yangxin Zhitong granule can significantly improve the clinical total effective rate of patients with chronic stable angina pectoris of Qi deficiency and blood stasis syndrome, effectively improve the symptoms of patients, play a role in lowering lipids and anti-inflammation, and improve the quality of life.