2024 年第 12 期 第 0 卷

青海地区2型糖尿病患者血清胱抑素C及尿酸水平与骨密度的相关性分析

Correlation analysis of serum cystatin C and uric acid levels with bone mineral density in patients with type 2 diabetes mellitus in Qinghai region

作者：谢延玲宋康林丽君姚勇利

英文作者：Xie Yanling Song Kang Lin Lijun Yao Yongli

单位：青海省人民医院内分泌科二病区，西宁810007

英文单位：Second Ward Department of Endocrinology Qinghai Provincial People′s Hospital Xining 810007 China

关键词：2型糖尿病；胱抑素C；血尿酸；骨密度

英文关键词：Type2diabetesmellitus;CystatinC;Serumuricacid;Bonedensity

• 摘要：

• 目的 探究青海地区2型糖尿病（T2DM）患者血清胱抑素C及尿酸水平与骨密度的相关性。方法 选取2023年1—12月在青海省人民医院内分泌科就诊的T2DM患者141例。根据骨质疏松症的诊断标准将患者分为骨量正常组（56例）、骨量减少组（53例）和骨质疏松组（32例），收集患者的一般资料，测定血清胱抑素C、尿酸等生化指标及骨密度数据，分析相关指标与骨密度的相关性。结果 3组性别分布、年龄及25-羟维生素D、胱抑素C、总胆固醇、高密度脂蛋白胆固醇水平比较差异均有统计学意义（均P<0.05）。将单因素分析差异有统计学意义的变量作为自变量纳入多因素有序Logistic回归分析模型，分析结果显示，年龄、胱抑素C是T2DM患者骨量减少及骨质疏松的危险因素，而男性、25-羟维生素D是其保护因素（比值比=0.434、0.922、1.100、3.555，均P<0.05）。结论 高水平血清胱抑素C、女性、高龄、低水平25-羟维生素D可能是青海地区T2DM患者骨量减少及骨质疏松症的危险因素，血尿酸水平与T2DM患者骨密度变化无显著相关性。

• Objective To investigate the correlation of serum cystatin C and uric acid levels with bone mineral density in patients with type 2 diabetes mellitus (T2DM) in Qinghai region. Methods A total of 141 T2DM patients who were treated in the Department of Endocrinology, Qinghai Provincial People′s Hospital from January to December 2023 were selected. According to the diagnostic criteria of osteoporosis, the patients were divided into normal bone mass group (56 cases), osteopenia group (53 cases) and osteoporosis group (32 cases). The general data of the patients were collected, serum cystatin C, uric acid and other biochemical indicators and bone mineral density data were measured, and the correlation between related indicators and bone mineral density was analyzed. Results There were significant differences in gender distribution, age, and levels of 25-hydroxyvitamin D, cystatin C, total cholesterol, and high-density lipoprotein cholesterol among the three groups (all P<0.05). The variables with statistically significant differences in univariate analysis were included in the multivariate ordinal Logistic regression analysis model as independent variables.The results showed that age and cystatin C were risk factors for osteopenia and osteoporosis, while male sex and 25-hydroxyvitamin D were protective factors (odds ratios=0.434, 0.922, 1.100, 3.555, all P<0.05). Conclusion High level of serum cystatin C, female, old age and low level of 25-hydroxyvitamin D may be risk factors for osteopenia and osteoporosis in T2DM patients in Qinghai province. There is no significant correlation between serum uric acid level and bone mineral density in T2DM patients.