2024 年第 9 期 第 0 卷

辅助性T细胞17/调节性T细胞及维甲酸相关孤儿受体γt/叉头框转录因子P3失衡在妊娠相关疾病中的研究进展

Research progress of T helper cell 17/regulatory T cell and retinoic acid-related orphan receptor γt/forkhead box transcription factor P3 imbalance in pregnancy-related diseases

作者：杨春燕1冯晓玲2

英文作者：Yang Chunyan1 Feng Xiaoling2

单位：1黑龙江中医药大学，哈尔滨150040；2黑龙江中医药大学附属第一医院妇科二科，哈尔滨150040

英文单位：1Heilongjiang University of Chinese Medicine Harbin 150040 China; 2Second Department of Gynecology Frist Affiliated Hospital Heilongjiang University of Chinese Medicine Harbin 150040 China

关键词：妊娠相关疾病；辅助性T细胞17；调节性T细胞；维甲酸相关孤儿受体γt；叉头框转录因子P3

英文关键词：Pregnancy-relateddiseases;Thelpercell17;RegulatoryTcell;Retinoicacid-relatedorphanreceptorγt;ForkheadboxtranscriptionfactorP3

• 摘要：

• 在免疫学领域，妊娠相当于一次成功的半同种移植现象，母体对半异体胎儿的免疫耐受情况关乎妊娠的结局。辅助性T细胞17（Th17）和调节性T细胞（Treg）是最新发现的CD+4 T淋巴细胞亚群，相关转录因子维甲酸相关孤儿受体γt和叉头框转录因子P3的表达水平与Th17/Treg之间的平衡密切相关。Th17/Treg免疫失衡会导致母体对胎儿的异常攻击，造成母胎耐受紊乱，并与复发性流产、先兆子痫、妊娠糖尿病等病理妊娠有关。

• In the field of immunology, pregnancy is equivalent to a successful semi-allograft phenomenon, and the maternal immune tolerance to the semi-allograft fetus is related to the outcome of pregnancy. Helper T cells 17 (Th17) and regulatory T cell (Treg) are newly discovered subsets of CD+4 T lymphocytes. The expression levels of related transcription factor retinoic acid-related orphan receptor γt and forkhead box transcription factor P3 are closely related to the balance between Th17/Treg. The Th17/Treg immune imbalance can lead to abnormal maternal attack on the fetus, resulting in maternal-fetal tolerance disorder, and is related to recurrent miscarriage, preeclampsia, gestational diabetes mellitus and other pathological pregnancy.