2024 年第 9 期 第 0 卷

心脏能量代谢在脓毒症心功能障碍中的研究进展

Research progress of cardiac energy metabolism in sepsis myocardial dysfunction

作者：李鑫鹏1杨小平2马雪纯3许哲敏4杨凯1彭鹏1马骏麒5

英文作者：Li Xinpeng1 Yang Xiaoping2 Ma Xuechun3 Xu Zhemin4 Yang Kai1 Peng Peng1 Ma Junqi5

单位：1新疆医科大学第一附属医院急救创伤中心，乌鲁木齐830011；2重庆两江新区人民医院重症医学科，重庆401121；3新疆医科大学第一附属医院护理部，乌鲁木齐830011；4广东省广州市第一人民医院急诊科，广州510180；5新疆医科大学附属中医医院急救创伤中心，乌鲁木齐830099

英文单位：1Emergency-Trauma Center the First Affiliated Hospital of Xinjiang Medical University Urumqi 830011 China; 2Department of Critical Care Medicine People′s Hospital of Chongqing Liangjiang New Area Chongqing 401121 China; 3Department of Nursing the First Affiliated Hospital of Xinjiang Medical University Urumqi 830011 China; 4Department of Emergency Guangzhou First People′s Hospital Guangdong Province Guangzhou 510180 China; 5Emergency-Trauma Center the Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University Urumqi 830099 China

关键词：脓毒症；心功能障碍；能量代谢

英文关键词：Sepsis；Myocardialdysfunction；Energymetabolism

• 摘要：

• 生理条件下，心脏中脂质、葡萄糖、酮体和氨基酸等能量物质代谢活动保持动态平衡，以满足心脏的能量需求。而在脓毒症期间，一些化学介质如内毒素、一氧化氮等引发的炎症反应以及某些信号通路的激活或抑制都会导致心脏能量代谢的改变，这既是机体代偿的过程，也是造成器官功能障碍的原因。本篇综述将着重探讨脓毒症期间的能量代谢变化，特别是心脏的能量代谢，旨在为治疗脓毒症所导致的心功能障碍提供新的研究方向和策略。

• Under physiological conditions, the metabolism of energy substances such as lipids, glucose, ketone bodies and amino acids in the heart maintains a dynamic balance to meet the energy needs of the heart. During sepsis, the inflammatory responses caused by some chemical mediators such as endotoxin and nitric oxide, as well as the activation or inhibition of certain signaling pathways, will lead to changes in cardiac energy metabolism, which is both a compensatory process and the cause of organ dysfunction. This review will focus on the changes in energy metabolism during sepsis, especially the energy metabolism of the heart, aiming to provide new research directions and strategies for the future treatment of cardiac dysfunction caused by sepsis.