2024 年第 8 期 第 0 卷

外泌体的抗炎抗衰老作用

The effects of anti-inflammatory and anti-aging of exosomes

作者：王雨莹1张晓彤1李玙璠2郝星3闫继红4

英文作者：Wang Yuying1 Zhang Xiaotong1 Li Yufan2 Hao Xing3 Yan Jihong4

单位：1首都医科大学基础医学院2020级五年制基础医学，北京100069；2首都医科大学附属北京潞河医院2020级五年制临床医学，北京101199；3首都医科大学附属北京安贞医院心外危重症中心，北京100029；4首都医科大学基础医学院组织胚胎学教研室，北京100069

英文单位：1Grade 2020 Five-year Basic Medicine School of Basic Medicine Capital Medical University Beijing 100069 China; 2Grade 2020 Five-year Clinical Medicine Beijing Luhe Hospital Capital Medical University Beijing 101199 China; 3Cardiac Surgical Critical Care Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China; 4Organization and Embryology Teaching and Research Office School of Basic Medicine Capital Medical University Beijing 100069 China

关键词：外泌体；抗炎；免疫调节；抗衰老；临床应用

英文关键词：Exosomes;Anti-inflammatory;Immuneregulation;Anti-aging;Clinicalapplication

• 摘要：

• 外泌体是一种纳米级别的囊泡，也是细胞间通讯的介质。外泌体由于特别的生物学效应以及组成而备受关注。许多研究表明外泌体具有调控机体免疫应答、细胞迁移、细胞分化、肿瘤侵袭等作用。本文着重综述其抗炎抗衰老机制，因为其复杂的机制不仅可以用于消除炎症，甚至还可以在一定程度上逆转组织器官的衰老，临床应用前景十分可观，可以应用于脑、皮肤、心脏等各个领域，有望解决许多疑难杂症。

• Exosomes are nanoscale vesicles and mediators of intercellular communication. Exosomes have attracted much attention due to their special biological effects and composition. Many studies have shown that exosomes regulate immune response, cell migration, cell differentiation, and tumor invasion. This article focuses on its anti-inflammatory and anti-aging mechanisms, because its complex mechanism can not only be used to eliminate inflammation, but also can reverse the aging of tissues and organs to a certain extent. Its clinical application prospect is very promising, and it can be applied to the brain, skin, heart and other fields, and is expected to solve many difficult and complicated diseases.