2024 年第 8 期 第 0 卷

补心宁神汤治疗心绞痛合并广泛性焦虑障碍的效果观察

The effect of Buxin Ningshen decoction in patients of angina pectoris complicated with generalized anxiety disorder

作者：李宁1徐佳音2李金宝1张辰浩1黄超联1杨国华3

英文作者：Li Ning1 Xu Jiayin2 Li Jinbao1 Zhang Chenhao1 Huang Chaolian1 Yang Guohua3

单位：1中国中医科学院望京医院急诊科，北京100102；2中国中医科学院望京医院特色诊疗中心，北京100102；3中国中医科学院望京医院心血管内科，北京100102

英文单位：1Department of Emergency Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102 China; 2Special Diagnosis and Treatment Center Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102 China; 3Department of Cardiovascular Medicine Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102 China

关键词：冠心病（冠状动脉粥样硬化性心脏病）；心绞痛；广泛性焦虑障碍；补心宁神汤；心胆气虚证

英文关键词：Coronaryatheroscleroticheartdisease;Anginapectoris;Generalizedanxietydisorder;BuxinNingshendecoction;HeartandgallQideficiencysyndrome

• 摘要：

• 目的 观察补心宁神汤治疗心绞痛合并广泛性焦虑障碍的临床效果。方法 选择2021年1月至2023年1月中国中医科学院望京医院急诊科收治的心绞痛合并广泛性焦虑障碍患者180例，按照随机数字表法分为观察组和对照组，每组90例。对照组采用常规西药治疗方案进行心绞痛规范化治疗、未针对焦虑用药；观察组在对照组的基础上针对焦虑加用补心宁神汤治疗；2组均治疗4周。比较2组治疗前后广泛性焦虑筛查量表（GAD-7）、躯体症状群量表（PHQ-15）评分，心绞痛发作频率和持续时间，左心室射血分数，中医证候评分，以及治疗期间不良反应发生情况。结果 治疗后观察组GAD-7和PHQ-15评分、心绞痛发作频率和持续时间、中医证候评分均明显低于/短于对照组、左心室射血分数高于对照组［（0.9±0.7）分比（3.4±1.4）分、（1.1±1.0）分比（3.7±2.1）分、（2.1±0.9）次/周比（4.1±1.2）次/周、（2.2±1.2）min/次比（4.8±2.2）min/次、（2.6±1.9）分比（8.9±2.9）分、（55±6）%比（51±7）%］，差异均有统计学意义（均P<0.05）。在整个治疗过程中2组均未出现明显不良反应。结论 补心宁神汤可有效缓解心绞痛合并广泛性焦虑障碍患者的症状，安全性良好。

• Objective To observe the clinical effect of Buxin Ningshen decoction in the treatment of angina pectoris complicated with generalized anxiety disorder. Methods  A total of 180 patients with angina pectoris and generalized anxiety disorder admitted to the Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences from January 2021 to January 2023 were selected, and they were divided into observation group and control group according to the random number table method, with 90 cases in each group. In the control group, conventional western medicine was used for standardized treatment of angina pectoris, but no medication targeting anxiety. The observation group was treated with Buxin Ningshen decoction for anxiety on the basis of the control group. Both groups were treated for 4 weeks. The generalized anxiety disorder 7-item (GAD-7) scale, patient health questionnaire 15（PHQ-15） scale scores, frequency and duration of angina pectoris, left ventricular ejection fraction, the score of traditional Chinese medicine syndrome, and occurrence of adverse reactions during treatment were compared between the two groups before and after treatment. Results  After treatment, the scores of GAD-7 and PHQ-15, the frequency and duration of angina pectoris, and the score of traditional Chinese medicine syndrome in the observation group were significantly lower than those in the control group, and the left ventricular ejection fraction was higher than that in the control group ［(0.9±0.7) vs (3.4±1.4), (1.1±1.0) vs (3.7±2.1), (2.1±0.9)times/week vs (4.1±1.2)times/week, (2.2±1.2)minutes/time vs (4.8±2.2)minutes/time, (2.6±1.9) vs (8.9±2.9), (55±6)% vs (51±7)%］(all P<0.05). There were no obvious adverse reactions in the two groups during the whole treatment. Conclusion  Buxin Ningshen decoction can effectively relieve the symptoms of patients with angina pectoris and generalized anxiety disorder with good safety.