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2024 年第 6 期 第 0 卷

消渴健脾方联合常规治疗与生酮饮食管理对气阴两虚证2型糖尿病患者的效果评价

Effect of Xiaoke Jianpi decoction combined with conventional treatment and ketogenic diet management in patients with type 2 diabetes mellitus with Qi and Yin deficiency syndrome

作者:魏晨曦1闫丽欣1杨阳2郜同心1叶海燕2

英文作者:Wei Chenxi1 Yan Lixin1 Yang Yang2 Gao Tongxin1 Ye Haiyan2

单位:1首都医科大学附属北京康复医院泌尿与代谢康复中心,北京100144;2首都医科大学附属北京康复医院中医康复诊疗中心,北京100144

英文单位:1Urinary and Metabolic Rehabilitation Center Beijing Rehabilitation Hospital Capital Medical University Beijing 100144 China; 2Traditional Chinese Medicine Rehabilitation Diagnosis and Treatment Center Beijing Rehabilitation Hospital Capital Medical University Beijing 100144 China

关键词:2型糖尿病;气阴两虚证;消渴健脾方;生酮饮食管理

英文关键词:Type2diabetesmellitus;QiandYindeficiencysyndrome;XiaokeJianpidecoction;Ketogenicdietmanagement

  • 摘要:
  • 目的 观察消渴健脾方联合常规治疗与生酮饮食管理对气阴两虚证2型糖尿病(T2DM)患者的临床疗效。方法 纳入2021年3月至2023年3月首都医科大学附属北京康复医院收治的120例气阴两虚证T2DM患者,按随机数字表法分为对照组和观察组,各60例。对照组给予常规治疗和生酮饮食管理治疗,观察组在对照组基础上给予消渴健脾方治疗。2组均治疗12周。比较2组治疗前后血糖指标、血脂指标、炎症指标、肠道菌群指标、临床疗效及不良反应发生情况。结果 对照组脱落2例,观察组脱落1例,最终对照组58例,观察组59例完成本研究。治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白、肿瘤坏死因子α、白细胞介素6、肠球菌丰度均低于对照组,而双歧杆菌、乳杆菌丰度均高于对照组(均P<0.05)。观察组治疗总有效率优于对照组[93.2%(55/59)比77.6%(45/58)],而不良反应总发生率低于对照组[8.5%(5/59)比27.6%(16/58)](均P<0.05)。结论 消渴健脾方联合常规治疗与生酮饮食管理可有效改善气阴两虚证T2DM患者糖脂代谢,降低炎症反应和调节肠道菌群,疗效较好,安全性较高。

  • Objective To observe the clinical efficacy of Xiaoke Jianpi decoction combined with conventional treatment and ketogenic diet management in patients with type 2 diabetes mellitus (T2DM) with Qi and Yin deficiency syndrome. Methods A total of 120 T2DM patients with Qi and Yin deficiency syndrome admitted to Beijing Rehabilitation Hospital, Capital Medical University from March 2021 to March 2023 were enrolled, and they were divided into control group and observation group according to the random number table method, with 60 cases in each group. The control group was given routine treatment and ketogenic diet management, and the observation group was treated with Xiaoke Jianpi decoction on the basis of the control group. Both groups were treated for 12 weeks. The blood glucose index, blood lipid index, inflammatory index, intestinal flora index, clinical efficacy and adverse reactions were compared between the two groups before and after treatment. Results There were 2 cases dropped off in the control group and 1 case dropped off in the observation group. Finally, 58 cases in the control group and 59 cases in the observation group completed this study. After treatment, the levels of fasting plasma glucose, 2 h postprandial plasma glucose, hemoglobin A1c, triacylglycerol, total cholesterol, low-density lipoprotein cholesterol, hypersensitive C-reactive protein, tumor necrosis factor-α, interleukin-6, and Enterococcus abundance in the observation group were lower than those in the control group, and the contents of Bifidobacterium abundance and Lactobacillus abundance in the observation group were higher than those in the control group (all P<0.05). The total effective rate of the observation group was better than that of the control group[93.2%(55/59) vs 77.6%(45/58)], the total incidence of adverse reactions in the observation group was lower than that in the control group [8.5%(5/59) vs 27.6%(16/58)] (both P<0.05). Conclusion Xiaoke Jianpi decoction combined with conventional treatment and ketogenic diet management can effectively improve glucose and lipid metabolism, reduce inflammatory response and regulate intestinal flora in T2DM patients with Qi and Yin deficiency syndrome, with good efficacy and high safety.

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