2024 年第 5 期 第 0 卷

自噬过程在多发性骨髓瘤中作用的研究进展

Research progress on autophagy in multiple myeloma

作者：周羿博 李莉娟 李燕鸿 张连生

英文作者：Zhou Yibo Li Lijuan Li Yanhong Zhang Liansheng

单位：兰州大学第二医院血液科，兰州730000

英文单位：Department of Hematology the Second Hospital Lanzhou University Lanzhou 730000 China

关键词：自噬；多发性骨髓瘤；耐药性；细胞增殖

英文关键词：Autophagy;Multiplemyeloma;Drugresistance;Cellproliferation

• 摘要：

• 多发性骨髓瘤（MM）是浆细胞异质性疾病。自噬是一种真核细胞维持内环境稳态的生物学过程，在MM的发生发展中具有双重作用，可以促进或抑制肿瘤的发展。本文就自噬及其调控机制、自噬在MM中的作用以及自噬相关的MM治疗策略等方面做一综述，以期为MM的临床诊治提供新思路。

• Multiple myeloma (MM) is a heterogeneous disease of plasma cells. Autophagy is a biological process of eukaryotic cells to maintain the homeostasis of the internal environment. It has a dual role in the occurrence and development of MM, which can promote or inhibit the development of tumor. This article reviews autophagy and its regulatory mechanism, the role of autophagy in MM, and the treatment strategies of autophagy-related MM, in order to provide new ideas for the clinical diagnosis and treatment of MM.