2024 年第 5 期 第 0 卷

磷酸二酯酶4抑制剂在皮肤病中应用的研究进展

Research progress on the application of phosphodiesterase 4 inhibitors in dermatosis

作者：彭欣欣1 牛旭平2

英文作者：Peng Xinxin1 Niu Xuping2

单位：1山西医科大学第九临床医学院皮肤科，太原030009；2山西医科大学附属太原市中心医院皮肤科，太原030009

英文单位：1Department of Dermatology the Ninth Clinical Medical College of Shanxi Medical University Taiyuan 030009 China; 2Department of Dermatology Taiyuan Central Hospital Affiliated to Shanxi Medical University Taiyuan 030009 China

关键词：皮肤病；磷酸二酯酶4；炎症因子

英文关键词：Dermatosis;Phosphodiesterase4;Inflammatoryfactors

• 摘要：

• 磷酸二酯酶4是在炎症细胞中代谢环磷酸腺苷的主要酶，并在调节第二信使的平衡中起着至关重要的作用。作为信号转导的关键调节因子，磷酸二酯酶4在多种疾病中显示出有希望的药理学靶点作用，其抑制剂已被用作治疗药物。本文综述了磷酸二酯酶4抑制剂治疗皮肤病的机制、疗效及不良反应。

• Phosphodiesterase 4 is the main enzyme that metabolizes cyclic adenosine monophosphate in inflammatory cells and plays a crucial role in regulating the balance of second messengers. As the key signal transduction regulation factor, phosphodiesterase 4 in a variety of diseases shows a promising pharmacological target, the inhibitors have been used as a treatment drug. This article reviews the mechanism, efficacy and adverse reactions of phosphodiesterase 4 inhibitors in the treatment of dermatosis.