2024 年第 5 期 第 0 卷

胰岛素抵抗与阿尔茨海默病的关联性研究进展

Research progress on the association between insulin resistance and Alzheimer′s disease

作者：朱徐锐1 陈昕露2 顾小萍1

英文作者：Zhu Xurui1 Chen Xinlu2 Gu Xiaoping1

单位：1南京医科大学鼓楼临床医学院南京鼓楼医院麻醉科，南京210008；2南京大学医学院附属鼓楼医院麻醉科，南京210008

英文单位：1Department of Anesthesiology Nanjing Drum Tower Hospital Drum Tower Clinical Medical College Nanjing Medical University Nanjing 210008 China; 2Department of Anesthesiology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing 210008 China

关键词：阿尔茨海默病；胰岛素抵抗；关联性；β淀粉样蛋白；tau蛋白；神经炎症

英文关键词：Alzheimer′sdisease;Insulinresistance;Association;Amyloid-β-protein;Tauprotein;Neuroinflammation

• 摘要：

• 随着中国老龄化人口的比例不断增加，阿尔茨海默病的发病率也随之升高。阿尔茨海默病作为最常见的神经退行性疾病，会表现出不可逆转的认知功能障碍。多项研究表明，胰岛素抵抗与阿尔茨海默病的β淀粉样蛋白异常积累、tau蛋白的异常以及神经炎症等发病机制具有关联性。本文系统总结了胰岛素抵抗与阿尔茨海默病的关联性及其可能机制。

• With the increasing proportion of aging population in China, the incidence of Alzheimer′s disease is also increasing. Alzheimer′s disease, the most common neurodegenerative disease, shows irreversible cognitive dysfunction. A number of studies have shown that insulin resistance is associated with the pathogenesis of Alzheimer′s disease, such as abnormal accumulation of amyloid-β-protein, abnormal tau protein, and neuroinflammation. This article systematically reviews the association between insulin resistance and Alzheimer′s disease and its possible mechanisms.