设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

2024 年第 3 期 第 19 卷

小儿肺咳颗粒联合硫酸沙丁胺醇治疗支气管哮喘患儿急性发作期的临床研究

Clinical study of Xiaoer Feike granule combined with salbutamol sulfate in treating children with bronchial asthma in acute attack

作者:齐海锋谈小云朱洁

英文作者:Qi Haifeng Tan Xiaoyun Zhu Jie

单位:江西省儿童医院儿内科,南昌330006

英文单位:Department of Pediatric Internal Medicine Jiangxi Provincial Children′s Hospital Nanchang 330006 China

关键词:支气管哮喘;急性发作;沙丁胺醇;小儿肺咳颗粒

英文关键词:Bronchialasthma;Acuteattack;Salbutamol;XiaoerFeikegranule

  • 摘要:
  • 目的 探讨小儿肺咳颗粒联合硫酸沙丁胺醇治疗支气管哮喘患儿急性发作期的效果。方法 选取2021年10月至2022年11月在江西省儿童医院接受治疗的支气管哮喘患儿84例,按随机数字表法将患儿分为对照组和观察组,各42例。对照组在常规治疗基础上采用硫酸沙丁胺醇雾化吸入溶液治疗;观察组在对照组基础上联合小儿肺咳颗粒口服治疗;2组均治疗7 d。比较2组的临床疗效以及治疗前后呼气峰值流速占预计值百分比(PEF%)、第1秒用力呼气容积占预计值百分比(FEV1%)、白细胞介素1β(IL-1β)、白三烯B4、C反应蛋白(CRP)、CD+3、CD+4、CD+8水平和不良反应发生情况。结果 观察组总有效率高于对照组[90.5%(38/42)比73.8%(31/42)](P=0.046)。治疗后,2组PEF%、FEV1%均高于治疗前,且观察组均高于对照组[(90±10)%比(85±10)%、(92±8)%比(88±8)%](均P<0.05);2组血清IL-1β、白三烯B4、CRP水平均低于治疗前,且观察组均低于对照组(均P<0.05);2组CD+3、CD+4水平均高于治疗前,且观察组均高于对照组,2组CD+8水平均低于治疗前,且观察组低于对照组(均P<0.05)。治疗期间,2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 小儿肺咳颗粒联合硫酸沙丁胺醇治疗支气管哮喘患儿急性发作期的效果较好,可有效改善患儿的肺功能及细胞免疫功能,降低炎症反应。

  • Objective To explore the curative effect of Xiaoer Feike granule combined with salbutamol sulfate in the treatment of children with bronchial asthma in acute stage. Methods Totally 84 children with bronchial asthma admitted to Jiangxi Provincial Children′s Hospital from October 2021 to November 2022 were enrolled. Children were divided into control group and observation group according to the random number table method, with 42 cases in each group. The control group was treated with salbutamol sulfate aerosol inhalation solution based on the routine treatment, and the observation group was treated with Xiaoer Feike granule based on the control group. Both groups were treated for 7 d. The clinical efficacy, and peak expiratory flow to percentage of expected value (PEF%), forced expiratory volume in first second to percentage of expected value (FEV1%), interleukin-1β (IL-1β), leukotriene B4, C-reactive protein (CRP), CD+3, CD+4, CD+8 levels before and after treatment as well as adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group[90.5%(38/42) vs 73.8%(31/42)](P=0.046). After treatment, PEF% and FEV1% of both groups were higher than those before treatment, and in the observation group were higher than those in control group[(90±10)% vs (85±10)%,(92±8)% vs (88±8)%](all P<0.05); serum levels of IL-1β, leukotriene B4 and CRP in both groups after treatment were lower than those before treatment and in the observation group were lower than those in control group (all P<0.05). Levels of CD+3 and CD+4 in both groups after treatment were higher than those before treatment and in the observation group were higher than those in control group; levels of CD+8 in both groups after treatment were lower than those before treatment and in the observation group was lower than those in control group (all P<0.05). There were no significant differences in adverse reaction rate between the observation group and the control group during treatment (P>0.05). Conclusion Xiaoer Feike granule combined with salbutamol sulfate is effective in treating children with bronchial asthma in acute attack, and can effectively improve the lung function and cellular immune function, and reduce inflammatory reaction.

copyright
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址: 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭
Baidu
map