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2024 年第 3 期 第 19 卷

通心络胶囊对痰湿体质高脂血症患者血脂及血清血管过氧化物酶1水平的影响

Effect of Tongxinluo capsule on levels of blood lipid and serum vascular peroxidase 1 in patients with phlegm-dampness constitution hyperlipidemia

作者:刘美之1边爱忠2王俊林2孙爱敏2安香珍1

英文作者:Liu Meizhi1 Bian Aizhong2 Wang Junlin2 Sun Aimin2 An Xiangzhen1

单位:1河北省石家庄市人民医院中医风湿骨病科,石家庄050011;2河北省衡水市景县中医医院中医科,衡水053500

英文单位:1Department of Traditional Chinese Medicine Shijiazhuang People′s Hospital Hebei Province Shijiazhuang 050011 China; 2Department of Traditional Chinese Medicine Jingxian Traditional Chinese Medicine Hospital in Hengshui City Hebei Province Hengshui 053500 China

关键词:高脂血症;痰湿体质;通心络胶囊;临床研究

英文关键词:Hyperlipidemia;Phlegm-dampnessconstitution;Tongxinluocapsule;Clinicalresearch

  • 摘要:
  • 目的 探讨通心络胶囊对痰湿体质高脂血症患者血脂及血清血管过氧化物酶1(VPO1)水平的影响。方法 选取2021年8月至2022年8月河北省衡水市景县中医医院收治的高脂血症患者200例。判定中医体质类型后选取其中的平和体质和痰湿体质患者分为3个研究组,平和体质患者为平和体质对照组,痰湿体质患者依照随机数字表法分为痰湿体质对照组和痰湿体质观察组。平和体质对照组、痰湿体质对照组给予阿托伐他汀钙片10 mg/次,1次/d晚上口服降脂治疗;痰湿体质观察组在前2组治疗基础上给予通心络胶囊3粒/次,3次/d口服治疗,3组均治疗4周。分析患者中医体质类型分布特点并观察不同体质类型患者血脂水平的差异。比较3组治疗前后的血脂、血清VPO1水平。结果 200例高脂血症患者中,痰湿体质患者最多,其次为气虚体质、血瘀体质,分别为55、40、34例,占比依次为27.5%、20.0%、17.0%。平和体质对照组、痰湿体质对照组、痰湿体质观察组分别为10、27、28例。痰湿体质、气虚体质高脂血症患者的总胆固醇显著高于其他各型,痰湿体质、血瘀体质和湿热体质患者的低密度脂蛋白胆固醇水平显著高于其他各型,差异均有统计学意义(均P<0.05)。治疗后,3组血脂总胆固醇、三酰甘油、低密度脂蛋白胆固醇、氧化型低密度脂蛋白、VPO1水平均低于治疗前且痰湿体质观察组低于平和体质对照组和痰湿体质对照组[VPO1:(145±9)ng/L比(150±8)、(178±11)ng/L],高密度脂蛋白胆固醇均高于治疗前且痰湿体质观察组高于平和体质对照组和痰湿体质对照组,差异均有统计学意义(均P<0.01)。结论 痰湿体质是高脂血症患者的主要体质类型,通心络胶囊能改善痰湿体质高脂血症患者的血脂水平,降低血清VPO1水平。

  • Objective To discuss the effect of Tongxinluo capsule on levels of blood lipid and serum vascular peroxidase 1(VPO1) in patients with phlegm-dampness constitution hyperlipidemia. Methods Totally 200 patients with hyperlipidemia admitted to Jingxian Traditional Chinese Medicine Hospital in Hengshui City, Hebei Province from August 2021 to August 2022 were selected. After determining the type of constitution in traditional Chinese medicine, patients with Pinghe constitution and phlegm-dampness constitution were selected and divided into three research groups. Patients with Pinghe constitution were divided into Pinghe constitution control group, while patients with phlegm-dampness constitution were divided into phlegm-dampness constitution control group and phlegm-dampness constitution observation group according to the random number table method. The Pinghe constitution control group and phlegm-dampness constitution control group were given atorvastatin calcium tablets 10 mg/time, once a day, and evening oral lipid-lowering treatment; the phlegm-dampness constitution observation group was treated with Tongxinluo capsule 3 capsules/time, 3 times/d orally, on the basis of the first two groups. All patients were treated for 4 weeks. Analyze the distribution characteristics of traditional Chinese medicine constitution types in patients and observe the differences in blood lipid levels among patients with different constitution types. The blood lipids and serum VPO1 levels were compared before and after treatment in three groups. Results Among the 200 patients with hyperlipidemia, phlegm-dampness constitution was the most common, followed by Qi deficiency constitution and blood stasis constitution, with 55, 40 and 34 cases, accounting for 27.5%, 20.0%, and 17.0%, respectively. There were 10 cases in the Pinghe constitution control group, 27 cases in the phlegm-dampness constitution control group, and 28 cases in thephlegm-dampness constitution observation group, respectively. The total cholesterol of hyperlipidemia patients with phlegm-dampness constitution, Qi deficiency constitution was significantly higher than that of other types; the low-density lipoprotein cholesterol levels of patients with phlegm-dampness constitution, blood stasis constitution, and damp heat constitution were significantly higher than that of other types(all P<0.05). After treatment, the levels of total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, and VPO1 in the three groups were lower than before treatment, and the phlegm dampness constitution observation group was lower than the Pinghe constitution control group and the phlegm-dampness constitution control group[VPO1: (145±9)ng/L vs (150±8), (178±11)ng/L], the high-density lipoprotein cholesterol levels in three groups were all higher than before treatment, and thephlegm-dampness constitution observation group was higher than the Pinghe constitution control group and phlegm-dampness constitution control group(all P<0.01). Conclusion Phlegm-dampness constitution is the main type of constitution in patients with hyperlipidemia. Tongxinluo capsule can improve the blood lipid level of phlegm-dampness constitution hyperlipidemia patients and reduce the levels of serum VPO1.

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