2024 年第 3 期 第 19 卷

新型冠状病毒感染对急性冠状动脉综合征患者住院期间主要不良心血管事件的影响

Effect of novel coronavirus infection on major adverse cardiovascular events during hospitalization in patients with acute coronary syndrome

作者：闫航语樊楚李丹董姝彤刘洁琳李志忠黄觊

英文作者：Yan Hangyu Fan Chu Li Dan Dong Shutong Liu Jielin Li Zhizhong Huang Ji

单位：首都医科大学附属北京安贞医院心内科冠心病中心六区，北京100029

英文单位：Sixth District of Coronary Heart Disease Center， Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：急性冠状动脉综合征；新型冠状病毒感染；临床特征；住院期间

英文关键词：Acutecoronarysyndrome;Novelcoronavirusinfection;Clinicalcharacteristics;Duringhospitalization

• 摘要：

• 目的 探究新型冠状病毒感染对于急性冠状动脉综合征（ACS）患者住院期间主要不良心血管事件（MACE）的影响。方法 对2022年12月至2023年1月首都医科大学附属北京安贞医院收治的因ACS入院的147例患者的临床资料进行分析。按照是否感染新型冠状病毒将患者分为合并新型冠状病毒感染组（49例）和未合并新型冠状病毒感染组（98例），比较2组的临床特征以及住院期间MACE的发生情况，采用Cox回归模型分析新型冠状病毒感染是否与患者住院期间发生MACE有独立关联。结果 ACS合并新型冠状病毒感染组患者的年龄、女性比例、D-二聚体水平、住院时间大于/高于/长于未合并新型冠状病毒感染组，淋巴细胞计数和入院后行血运重建比例低于未合并新型冠状病毒感染组（均P＜0.05）。合并新型冠状病毒感染组住院期间MACE的发生率显著高于未合并新型冠状病毒感染组 ［32.7%(16/49)比11.2%(11/98)］（P=0.002）。多因素Cox回归分析显示，新型冠状病毒感染是ACS患者住院期间MACE的独立危险因素（风险比=3.217，95%置信区间:1.151～8.987，P=0.031）。结论 新型冠状病毒感染可增加ACS患者住院期间MACE的发生率。

• Objective To investigate the effect of novel coronavirus infection on major adverse cardiovascular events (MACE) during hospitalization in patients with acute coronary syndrome (ACS). Methods Clinical data of 147 patients with ACS admitted to Beijing Anzhen Hospital, Capital Medical University from December 2022 to January 2023 were analyzed. Patients were divided into the novel coronavirus infection group (98 cases) and the non infection group (49 cases) according to whether it was infected with novel coronavirus. The clinical characteristics and incidence of MACE during hospitalization were compared between the two groups. Cox regression model was used to analyze the independent correlation between novel coronavirus infection and MACE during hospitalization. Results The age, proportion of females, D-Dimer level and length of stay of novel coronavirus infection group were greater/higher/longer than those of non infection group and the lymphocyte level and the proportion of revascularization after admission were lower than those of non infection group (all P<0.05). The incidence of MACE during hospitalization of novel coronavirus infection group was significantly higher than that of non infection group ［32.7%(16/49) vs 11.2%(11/98)］(P=0.002). Multivariate Cox regression analysis showed that novel coronavirus infection was independently associated with MACE during hospitalization in patients with ACS (hazard ratio=3.217，95% confidence interval: 1.151-8.987, P=0.031). Conclusion Novel coronavirus infection can increase the incidence of MACE during hospitalization in patients with ACS.