2024 年第 2 期 第 19 卷

益气补血方联合早期康复功能锻炼治疗早期胃癌根治术后气血两虚证的效果研究

Efficacy of combining early rehabilitation functional exercise with the Yiqi Buxue recipe in the treatment of Qi and blood deficiency after radical surgery for early gastric cancer

作者：刘莉1康春博1郝伶俐2秘西花1

英文作者：Liu Li1 Kang Chunbo1 Hao Lingli2 Mi Xihua1

单位：1首都医科大学附属北京康复医院胃肠康复中心，北京100144；2首都医科大学附属北京康复医院中医康复诊疗中心，北京100144

英文单位：1Gastrointestinal Rehabilitation Center Beijing Rehabilitation Hospital Capital Medical University Beijing 100144 China; 2Chinese Medicine Rehabilitation Treatment Center Beijing Rehabilitation Hospital Capital Medical University Beijing 100144 China

关键词：早期胃癌；根治切除术；康复功能锻炼；益气补血方；气血两虚证

英文关键词：Earlygastriccancer;Radicalresection;Rehabilitationfunctionalexercise;YiqiBuxuerecipe;Qiandblooddeficiency

• 摘要：

• 目的  观察益气补血方联合早期康复功能锻炼治疗早期胃癌根治术后气血两虚证的临床效果。方法  选取2020年6月至2022年12月首都医科大学附属北京康复医院收治的110例早期胃癌根治术后气血亏虚证患者为研究对象，根据随机数字表法分为对照组和观察组，各55例。对照组给予胃癌根治术后西医常规治疗及早期康复功能锻炼，观察组在对照组基础上给予益气补血方治疗。分别对2组患者中医临床症状积分、胃肠功能恢复情况、营养状况、免疫功能及胃肠道不良反应进行对比分析。结果  对照组脱落1例、观察组脱落2例，最终对照组54例、观察组53例患者完成本研究。术后30 d，2组临床症状积分均低于术前，且观察组低于对照组［（16±3）分比（18±4）分］（均P＜0.001）。观察组术后胃肠鸣音恢复时间、首次肛门排气时间、首次排便时间均短于对照组（均P＜0.001)。术后30 d，2组血红蛋白、转铁蛋白、总蛋白、免疫球蛋白A（IgA）、IgG、IgM、CD+4、CD+4/CD+8比值均高于治疗前、且观察组均高于对照组，2组CD+8均低于术前、且观察组低于对照组（均P＜0.05）。2组不良反应总发生率比较差异无统计学意义（P＞0.05）。结论  益气补血方联合早期康复功能锻炼治疗早期胃癌根治术后气血两虚证可有效促进胃肠功能恢复、营养状况改善和免疫功能恢复。

• Objective  To observe the clinical efficacy of the combination of Yiqi Buxue recipe with early rehabilitation functional exercise in the treatment of early gastric cancer post-radical surgery with Qi and blood deficiency. Methods  Totally 110 patients admitted to Beijing Rehabilitation Hospital, Capital Medical University from June 2020 to December 2022 after radical surgery for gastric cancer were included as study subjects. They were divided into control group and observation group according to the random number table method, with 55 cases each. The control group was given conventional western medical treatment and early rehabilitation functional exercise, and the observation group was given Yiqi Buxue recipe treatment on the basis of the control group. The traditional Chinese medicine clinical symptom score, recovery of gastrointestinal function, nutritional status, immune function, and gastrointestinal adverse reactions of the two groups patients were compared and analyzed. Results  There was 1 case of detachment in the control group and 2 cases in the observation group, and finally 54 cases in the control group and 53 cases in the observation group completed this study. The traditional Chinese medicine clinical symptom scores 30 d after surgery in both groups were lower than those before surgery, and the score in the observation group was lower than that in the control group ［（16±3）vs（18±4）］(all P＜0.001). The time of recovery of gastrointestinal sounds, time of first anal venting and time of first defecation after surgery in the observation group were shorter than those in the control group (all P<0.001). After 30 d of surgery, levels of hemoglobin, transferrin, total protein, immunoglobulin A (IgA), IgG, IgM, CD+4 and CD+4/CD+8 ratio in both groups were higher than those before surgery, and the observation group was higher than the control group; the level of CD+8 in both groups was lower than that before surgery, and the observation group was lower than the control group (all P<0.05). There was no significant difference in total rate of adverse reactions between the two groups (P＞0.05). Conclusion  Yiqi Buxue recipe combined with early rehabilitation functional exercise for the treatment of qi and blood deficiency evidence after early gastric cancer radical surgery can effectively promote the recovery of gastrointestinal function, improvement of nutritional status and recovery of immune function.