设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

2024 年第 2 期 第 19 卷

左乙拉西坦片联合维生素B12片治疗儿童癫痫的临床研究

Clinical study of levetiracetam tablets combined with vitamin B12 tablets in the treatment of childhood epilepsy

作者:全小宁1楚乐1孙小春2

英文作者:Quan Xiaoning1 Chu Le1 Sun Xiaochun2

单位:1三二〇一医院儿科,汉中723000;2陕西省榆林市第二医院药剂科,榆林719000

英文单位:1Department of Paediatrics 3201 Hospital Hanzhong 723000 China; 2Department of Pharmacy Yulin Second Hospital Shaanxi Province Yulin 719000 China

关键词:癫痫;左乙拉西坦片;维生素B12片

英文关键词:Epilepsy;Levetiracetamtablets;VitaminB12tablets

  • 摘要:
  • 目的  探讨左乙拉西坦片联合维生素B12片对儿童癫痫的治疗效果。方法  选取2020年1月至2022年8月在三二〇一医院接受治疗的癫痫患儿88例,将其按随机数字表法分为对照组(n=44)和观察组(n=44)。对照组患儿采用左乙拉西坦片进行治疗,观察组患儿采用左乙拉西坦片联合维生素B12片进行治疗。治疗6个月后比较2组的总有效率,治疗前后癫痫发作频率、每次发作持续时间以及血清同型半胱氨酸(Hcy)、S-100β、神经元特异性烯醇化酶(NSE)水平和不良反应发生情况。结果  观察组的总有效率高于对照组[90.9%(40/44)比75.0%(33/44)],差异有统计学意义(P=0.047)。与治疗前比较,2组患儿治疗后癫痫发作频率均明显降低,每次发作持续时间均明显减少,且观察组癫痫发作频率低于、每次发作时间少于对照组(均P<0.05)。2组患儿治疗后血清Hcy水平明显高于治疗前、血清S-100β以及NSE水平均明显低于治疗前,且观察组血清Hcy、S-100β以及NSE水平均低于对照组(均P<0.05)。2组总不良反应发生率比较,差异无统计学意义(P=0.437)。结论  左乙拉西坦片联合维生素B12片治疗儿童癫痫安全有效,可作为临床治疗癫痫患儿的有效手段。

  • Objective  To explore the therapeutic effect of levetiracetam tablets combined with vitamin B12 tablets on childhood epilepsy. Methods  A total of 88 children with epilepsy who were treated in 3201 Hospital from January 2020 to August 2022 were selected and divided into the control group (44 cases) and the observation group (44 cases) according to the random number table method. The control group was treated with levetiracetam tablets, and the observation group was treated with levetiracetam tablets combined with vitamin B12 tablets. After 6 months of treatment, the total effective rate, the frequency and duration of seizures, the levels of serum homocysteine (Hcy), S-100β and neuron specific enolase (NSE) before and after treatment, and the adverse reactions were compared between the two groups. Results  The total effective rate of the observation group was higher than that of the control group[90.9%(40/44) vs 75.0%(33/44)] (P=0.047). Compared before treatment, the frequency and duration of seizures in the two groups after treatment were significantly reduced, and the frequency and duration of seizures in the observation group were lower than those in the control group (all P<0.05). The levels of serum Hcy in the two groups after treatment were significantly higher than those before treatment, while the levels of serum S-100β and NSE in the two groups after treatment were significantly lower than those before treatment, and the levels of serum Hcy, S-100β and NSE in the observation group were lower than those in the control group (all P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P=0.437). Conclusion  Levetiracetam tablets combined with vitamin B12 tablets is safe and effective in the treatment of childhood epilepsy, and can be used as an effective method for clinical treatment of children with epilepsy.

copyright
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址: 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭
Baidu
map