2024 年第 2 期 第 19 卷

调强放疗联合康莱特注射液治疗老年非小细胞肺癌的临床效果及对患者免疫功能的影响观察

Clinical effect of intensity modulated radiotherapy combined with Kanglaite injection in the treatment of elderly patients with non-small cell lung cancer and its effect on immune function

作者：王晓贞杨立鑫李丹青乔志安

英文作者：Wang Xiaozhen Yang Lixin Li Danqing Qiao Zhian

单位：河北省邢台市人民医院放疗科，邢台054000

英文单位：Department of Radiotherapy Xingtai People′s Hospital Hebei Province Xingtai 054000 China

关键词：老年非小细胞肺癌；调强放疗；康莱特注射液；免疫功能；临床效果

英文关键词：Elderlynon-smallcelllungcancer;Intensitymodulatedradiotherapy;Kanglaiteinjection;Immunefunction;Clinicaleffect

• 摘要：

• 目的  观察调强放疗联合康莱特注射液治疗老年非小细胞肺癌（NSCLC）的临床效果及对患者免疫功能的影响。方法  选取2018年1月至2019年8月于河北省邢台市人民医院就诊的老年NSCLC患者90例，根据治疗方式不同分为对照组和观察组，各45例，患者按完全自愿原则分别加入上述2组。对照组采用调强放疗（5~6周完成），观察组采用调强放疗联合康莱特注射液治疗（静脉滴注连续3周）。记录2组患者治疗前及治疗结束1个月后情况，比较近期疗效、Karnofsky功能状态（KPS）评分、不良反应情况和免疫功能指标水平。结果  2组客观缓解率比较差异无统计学意义（P=0.606）。观察组KPS评分提高率高于对照组［64.4%（29/45）比37.8%（17/45）］，差异有统计学意义（P=0.020）。观察组白细胞减少发生率低于对照组［13.3%（6/45）比66.7%（15/45）］（P=0.045）。治疗后，2组CD+4、CD+4/CD+8比值、自然杀伤细胞水平均高于治疗前且观察组高于对照组，CD+8水平均低于治疗前且观察组低于对照组，差异均有统计学意义（均P<0.05）。结论  调强放疗联合中药康莱特注射液治疗能改善老年NSCLC患者的生活质量，降低不良反应发生率，提高免疫功能。

• Objective  To observe the clinical effect of intensity modulated radiotherapy(IMRT) combined with Kanglaite injection in the treatment of elderly patients with non-small cell lung cancer(NSCLC) and its effect on immune function. Methods  Totally 90 elderly NSCLC patients who were treated in Xingtai People′s Hospital, Hebei Province from January 2018 to August 2019 were selected, and they were divided into control group and observation group according to different treatment methods, with 45 cases in each group. Patients were added to the two groups according to the principle of complete voluntary participation. The control group was treated with IMRT (completed in 5-6 weeks), while the observation group was treated with IMRT combined with Kanglaite injection (intravenous infusion for 3 consecutive weeks). The condition of two groups of patients was recorded before treatment and 1 month after the end of treatment, and the recent efficacy, Karnofsky performance status (KPS) score, adverse reactions, and immune function index levels were compared. Results  There was no statistically significant difference in objective response rates between the two groups(P=0.606). The improvement rate of KPS score in the observation group was higher than that in the control group［64.4%(29/45) vs 37.8%(17/45)］ (P=0.020). The incidence of leukopenia in the observation group was lower than that in the control group［13.3%(6/45) vs 66.7%(15/45)］(P=0.045). After treatment, the levels of CD+4, CD+4/CD+8 ratio, and natural killer cell in both groups were higher than those before treatment, and the observation group was higher than the control group; the CD+8 level was lower than that before treatment, and the observation group was lower than the control group (all P<0.05). Conclusion  IMRT combined with traditional Chinese medicine Kanglaite injection can improve the quality of life of elderly patients with NSCLC, reduce the incidence of adverse reactions, and improve the immune function.