2024 年第 1 期 第 19 卷

酯化酶甾醇O-酰基转移酶1在恶性肿瘤中作用的研究进展

Research progress on effect of esterifying enzyme sterol O-acyltransferase 1 in malignant tumors

作者：王亮1 黄幼生2 符谨诚1 邹科见1

英文作者：Wang Liang1 Huang Yousheng2 Fu Jincheng1 Zou Kejian1

单位：1海南省人民医院/海南医学院附属海南医院胃肠外科，海口570100；2海南医学院第一附属医院病理科，海口570100

英文单位：1Department of Gastrointestinal Surgery Hainan General Hospital Hainan Hospital Affiliated to Hainan Medical College Haikou 570100 China; 2Department of Pathology the First Affiliated Hospital of Hainan Medical College Haikou 570100 China

关键词：恶性肿瘤；甾醇O-酰基转移酶1；胆固醇；研究进展

英文关键词：Malignanttumor;SterolO-acyltransferase1;Cholesterol;Researchprogress

• 摘要：

• 甾醇O-酰基转移酶1（SOAT1）是一种位于内质网内的酯化酶，催化细胞内游离胆固醇转化为脂滴。SOAT1被发现在多种恶性肿瘤内高表达，并与恶性肿瘤增殖、侵袭迁移紧密相关。这表明SOAT1有潜力成为恶性肿瘤早期诊断的生物标志物和治疗新靶点。本文就SOAT1的结构、功能及其在恶性肿瘤中作用的相关研究进展进行综述。

• Sterol O-acyltransferase 1 (SOAT1) is an esterifying enzyme located in the endoplasmic reticulum that catalyzes the conversion of intracellular free cholesterol into lipid droplets. SOAT1 has been found to be highly expressed in a variety of malignant tumors, and is closely related to the proliferation, invasion and migration of malignant tumors. This indicates that SOAT1 has the potential to be a biomarker for the early diagnosis of malignant tumors and a new therapeutic target. This reviews the structure and function of SOAT1 and its role in malignant tumors.