2023 年第 12 期 第 18 卷

非酒精性脂肪性肝病发病机制的研究进展

Research progress on the pathogenesis of non-alcoholic fatty liver disease

作者：杨小雄1杨帆2魏小果2

英文作者：Yang Xiaoxiong1 Yang Fan2 Wei Xiaoguo2

单位：1甘肃中医药大学第一临床医学院，兰州730000；2甘肃省人民医院干部消化科，兰州730000

英文单位：1First Clinical Medical College Gansu University of Chinese Medicine Lanzhou 730000 China; 2Department of Cadre Gastroenterology Gansu Provincial Hospital Lanzhou 730000 China

关键词：非酒精性脂肪性肝病；代谢；氧化应激；遗传因素；自主神经

英文关键词：Non-alcoholicfattyliverdisease;Metabolism;Oxidativestress;Geneticfactors;Autonomicnerve

• 摘要：

• 非酒精性脂肪性肝病（NAFLD）是一种与胰岛素抵抗密切相关的代谢应激性肝损伤，是目前世界上最常见的慢性肝病，可导致肝硬化、肝细胞癌和终末期肝病。针对NAFLD，临床上暂时无特异性的治疗措施。本文就近几年来国内外关于NAFLD的发病机制及危险因素的最新进展进行综述，如代谢相关因素、肠道微生态紊乱、氧化应激、遗传、自主神经系统等，旨在为临床治疗NAFLD提供新的思路。

• Non-alcoholic fatty liver disease (NAFLD) is a metabolic irritability liver injury closely related to insulin resistance. It is the most common chronic liver disease in the world at present, which can lead to cirrhosis, hepatocellular carcinoma and end-stage liver disease. There are currently no specific treatment measures for NAFLD in clinical practice. This article reviews the latest progress in the pathogenesis and risk factors of NAFLD at home and abroad in recent years, such as metabolism related factors, intestinal microecology disorder, oxidative stress, genetics, autonomic nervous system, etc., in order to provide new ideas for clinical treatment of NAFLD.