2023 年第 12 期 第 18 卷

香砂六君子汤加减对胃癌患者术后肠黏膜屏障及免疫状态的影响

Effects of modified Xiangsha Liujunzi decoction on intestinal mucosal barrier and immune status in patients with gastric cancer after surgery

作者：唐潇然1呼健1赵鹏飞2

英文作者：Tang Xiaoran1 Hu Jian1 Zhao Pengfei2

单位：1解放军总医院第六医学中心中医医学部，北京100048；2北京中医药大学东方医院肿瘤科，北京100078

英文单位：1Department of Traditional Chinese Medicine the Sixth Medical Center of PLA General Hospital Beijing 100048 China; 2Department of Oncology Dongfang Hospital Beijing University of Chinese Medicine Beijing 100078 China

关键词：胃癌；香砂六君子汤加减；肠黏膜屏障；免疫状态

英文关键词：Gastriccancer;ModifiedXiangshaLiujunzidecoction;Intestinalmucosalbarrier;Immunestatus

• 摘要：

• 目的  探究香砂六君子汤加减对胃癌患者术后肠黏膜屏障及免疫状态的影响。方法  选取2021年1月至2022年2月于解放军总医院诊治的胃癌患者100例，经筛查和排除后，最终纳入统计89例，其中对照组40例、观察组49例。2组患者术后均给予常规治疗，观察组在常规治疗基础上给予香砂六君子汤加减治疗，2组患者均连续治疗7 d。比较2组患者中医证候积分、肠黏膜屏障指标、胃激素水平、细胞免疫指标和体液免疫指标。结果  2组患者治疗后便秘、腹胀、腹痛、呃逆评分和D-乳酸、二胺氧化酶、CD+8水平均低于治疗前，且观察组低于对照组［（1.48±0.16）分比（1.90±0.22）分，（1.12±0.13）分比（1.72±0.20）分，（1.11±0.12）分比（1.58±0.17）分，（1.22±0.14）分比（1.65±0.18）分，（6.1±0.8）mg/L比（8.2±1.0）mg/L，（16.2±1.7）kU/L比（20.6±2.1）kU/L，（22.0±2.1）%比（25.3±2.6）%］，差异均有统计学意义（均P＜0.05）。2组患者治疗后胃动素、胃泌素、CD+3、CD+4、免疫球蛋白A、免疫球蛋白M、免疫球蛋白G水平均高于治疗前，且观察组高于对照组，差异均有统计学意义（均P＜0.05）。结论  胃癌患者术后应用香砂六君子汤可修复肠黏膜屏障，增强机体免疫，改善胃激素水平。

• Objective To investigate the effects of modified Xiangsha Liujunzi decoction on intestinal mucosal barrier and immune status in patients with gastric cancer after surgery. Methods From January 2021 to February 2022, 100 patients with gastric cancer diagnosed and treated in PLA General Hospital were selected. After screening and exclusion, 89 patients were finally included in the statistics, including 40 cases in the control group and 49 cases in the observation group. Patients were given routine treatment after surgery in the two groups, and the observation group was given modified Xiangsha Liujunzi decoction treatment on the basis of routine treatment. Patients were continuously treated for 7 d in the two groups. The traditional Chinese medicine syndrome scores, intestinal mucosal barrier indicators, gastric hormone levels, cellular immune indicators and humoral immune indicators of patients were compared between the two groups. Results  The scores of constipation, abdominal distension, abdominal pain and hiccup and the levels of D-lactic acid, diamine oxidase and CD+8 of patients after treatment were lower than those before treatment in the two groups, and the observation group was lower than the control group［(1.48±0.16) vs (1.90±0.22), (1.12±0.13) vs (1.72±0.20), (1.11±0.12) vs (1.58±0.17), (1.22±0.14) vs (1.65±0.18), (6.1±0.8)mg/L vs (8.2±1.0)mg/L, (16.2±1.7)kU/L vs (20.6±2.1)kU/L, (22.0±2.1)% vs (25.3±2.6)%］(all P＜0.05). The levels of motilin, gastrin, CD+3, CD+4, immunoglobulin A, immunoglobulin M and immunoglobulin G of patients after treatment were higher than those before treatment in the two groups, and the observation group was higher than the control group (all P＜0.05). Conclusion Postoperative application of Xiangsha Liujunzi decoction in patients with gastric cancer can repair the intestinal mucosal barrier, enhance the body′s immunity, and improve the gastric hormones level.