2023 年第 11 期 第 18 卷

帕金森病患者血清炎症因子与抑郁和焦虑的相关性分析

Correlation of serum inflammatory factors with depression and anxiety in patients with Parkinson′s disease

作者：任伯韩博雅刘斌米唤金云静孙宝莹

英文作者：Ren Bo Han Boya Liu Bin Mi Huanjin Yun Jing Sun Baoying

单位：华北理工大学附属医院神经内一科，唐山063000

英文单位：First Department of Neurology North China University of Science and Technology Affiliated Hospital Tangshan 063000 China

关键词：帕金森病；抑郁；焦虑；炎症因子

英文关键词：Parkinson′sdisease;Depression;Anxiety;Inflammatoryfactors

• 摘要：

• 目的  探讨血清炎症因子NOD样受体家族蛋白3（NLRP3）、肿瘤坏死因子α（TNF-α）和白细胞介素1β（IL-1β）与帕金森病患者抑郁和焦虑的关系。方法  连续选取于2020年1—12月在华北理工大学附属医院神经内科住院治疗的帕金森病患者60例作为研究对象。对所有患者进行汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评分，根据HAMD评分情况将患者分为无抑郁组、轻度抑郁组、中度抑郁组、重度抑郁组，根据HAMA评分情况将患者分为无焦虑组、轻度焦虑组、中度焦虑组、重度焦虑组。检测患者血清NLRP3、TNF-α和IL-1β水平，分析相关血清炎症因子与帕金森病患者抑郁和焦虑的相关性。结果  无抑郁组、轻度抑郁组、中度抑郁组、重度抑郁组患者血清NLRP3、TNF-α、IL-1β水平比较差异均有统计学意义，抑郁程度越重，各因子水平越高（均P＜0.05）。血清NLRP3、TNF-α、IL-1β水平与帕金森病患者HAMD评分呈正相关（r=0.871、0.723、0.687，P=0.002、0.040、0.020）。无焦虑组、轻度焦虑组、中度焦虑组、重度焦虑组患者血清NLRP3、TNF-α、IL-1β水平比较差异均有统计学意义，焦虑程度越重，各因子水平越高（均P＜0.05）。血清NLRP3、TNF-α、IL-1β水平与帕金森病患者HAMA评分呈正相关（r=0.854、0.664、0.627，P=0.001、0.030、0.020）。结论  血清炎症因子NLRP3、TNF-α、IL-1β水平与帕金森病患者抑郁、焦虑密切相关，抑郁、焦虑程度越重，炎症因子水平越高。

• Objective  To explore the correlation of serum inflammatory factor NOD-like receptor protein 3 (NLRP3), tumor necrosis factor-α（TNF-α） and interleukin-1β（IL-1 β）with depression and anxiety in patients with Parkinson′s disease (PD). Methods  Totally 60 patients with PD admitted to North China University of Science and Technology Affiliated Hospital from January to December 2020 were enrolled. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) scores of patients were evaluated, and they were divided into non depression group, mild depression group, moderate depression group and severe depression group according to HAMD, and non anxiety group, mild anxiety group, moderate anxiety group and severe anxiety group according to HAMA, respectively. Levels of serum NLRP3, TNF-α and IL-1β of patients were detected, and the correlation of serum inflammatory factors with depression and anxiety in patients with PD was analyzed. Results  There were significant differences in serum levels of NLRP3, TNF-α and IL-1β among non depression group, mild depression group, moderate depression group and severe depression group, the greater the degree of depression, the higher the level of factors (all P<0.05). Serum levels of NLRP3, TNF-α and IL-1β were positively correlated with HAMD score in patients with PD （r=0.871, 0.723, 0.687; P=0.002,0.040,0.020）. There were significant differences in serum levels of NLRP3, TNF-α and IL-1β among non anxiety group, mild anxiety group, moderate anxiety group and severe anxiety group, the greater the degree of anxiety, the higher the level of factors (all P<0.05). Serum levels of NLRP3, TNF-α and IL-1β were positively correlated with HAMA score in patients with PD（r=0.854, 0.664, 0.627; P=0.001, 0.030, 0.020）. Conclusions    erum levels of inflammatory factors NLRP3, TNF-α and IL-1β were closely related to depression and anxiety in patients with PD, the greater the degree of depression and anxiety, the higher the level of inflammatory factors.