2023 年第 10 期 第 18 卷

瑞马唑仑与丙泊酚用于无痛胃镜检查麻醉效果的比较研究

Comparison of the effect of remimazolam and propofol on painless gastroscopy anesthesia

作者：杨铭1王克胜2翁洪亮2任永颖2李志冰2李玉见2朱喆2李兴达2

英文作者：Yang Ming1 Wang Kesheng2 Weng Hongliang2 Ren Yongying2 Li Zhibing2 Li Yujian2 Zhu Zhe2 Li Xingda2

单位：1山东第一医科大学研究生部，济南250000；2山东省临沂市中心医院麻醉科，临沂276400

英文单位：1Graduate School of Shandong First Medical University Jinan 250000 China; 2Department of Anesthesiology Linyi Central Hospital Shandong Province Linyi 276400 China

关键词：无痛胃镜；丙泊酚；瑞马唑仑；静脉麻醉

英文关键词：Painlessgastroscopy;Propofol;Remimazolam;Intravenousanesthesia

• 摘要：

• 目的  以丙泊酚为对照，探究瑞马唑仑在无痛胃镜麻醉中的安全性及有效性。方法  选取2022年5—7月临沂市中心医院接受无痛胃镜检查的受试者80例，根据随机数字表法分为丙泊酚组和瑞马唑仑组,每组40例。2组受试者均静脉给予50 μg/kg地佐辛，2 min后丙泊酚组和瑞马唑仑组受试者分别静脉给予2 mg/kg丙泊酚和0.2 mg/kg甲苯磺酸瑞马唑仑，操作中根据实际情况追加药物。比较2组受试者一般情况、给药前及给药结束进镜后2、4和6 min的平均动脉压和心率、术中不良反应发生情况、苏醒情况。结果  瑞马唑仑组受试者进镜后2、4以及6 min的平均动脉压和心率均高于丙泊酚组，差异均有统计学意义（均P<0.05）。瑞马唑仑组呃逆发生率高于、呼吸抑制发生率低于丙泊酚组［17.5%（7/40）比0（0/40）、7.5%（3/40）比25.0%（10/40）］，差异均有统计学意义（均P<0.05）。瑞马唑仑组受试者苏醒时间短于丙泊酚组，麻醉后恢复室停留时间长于丙泊酚组，差异均有统计学意义（均P<0.05）。结论  相较于丙泊酚，瑞马唑仑在无痛胃镜检查中对受试者的呼吸系统和循环系统的抑制作用更小，不良反应发生率更低。

• Objective  Using propofol as a control, to investigate the safety and efficacy of remimazolam in painless gastroscopic anesthesia. Methods  From May to July 2022, 80 subjects underwent painless gastroscopy in Linyi Central Hospital were selected. They were divided into propofol group and remimazolam group according to the random number table method, with 40 cases in each group. Both groups were given 50 μg/kg dezocine intravenously, and the propofol group and remimazolam group were given 2 mg/kg propofol and 0.2 mg/kg remimazolam tosilate at 2 min later, respectively. Additional drugs were added according to the actual situation during the operation. Results  The mean arterial pressure and heart rate in the remimazolam group were higher than those in the propofol group at 2, 4 and 6 min after endoscopy (all P<0.05). The incidence of hiccup in remimazolam group was higher and the incidence of respiratory depression in remimazolam group was lower than those in propofol group［17.5%（7/40） vs 0（0/40）, 7.5%（3/40） vs 25.0%（10/40）］(P<0.05). The recovery time of subjects in remimazolam group was shorter than that in propofol group, and the stay time in postanesthesia care unit was longer than that in propofol group (both P<0.05). ConclusionsCompared with propofol, remimazolam has less inhibitory effect on the respiratory system and circulatory system of the subject during painless gastroscopy, and the incidence of adverse reactions is lower.