2023 年第 6 期 第 18 卷

系统性红斑狼疮合并大疱皮损1例

A case report of systemic lupus erythematosus complicated with bullous lesions

作者：熊鸿罗丰袁雪梅周勇马武开姚血明

英文作者：Xiong Hong Luo Feng Yuan Xuemei Zhou Yong Ma Wukai Yao Xueming

单位：贵州中医药大学第二附属医院风湿免疫科，贵阳550001

英文单位：Department of Rheumatism and Immunology the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001 China

关键词：系统性红斑狼疮；大疱皮损；定期随访

英文关键词：Systemiclupuserythematosus;Bullouslesions;Regularfollow-up

• 摘要：

• 系统性红斑狼疮（SLE）是一种异质性自身免疫性疾病，极少数情况下会出现大疱皮损。本文报道1例SLE伴大疱皮损患者，该患者SLE患病5年，随访4年间疾病整体控制稳定，突发1次大疱皮损，经中西医结合诊治大疱皮损已愈合。SLE发病机制复杂，病因尚未明确，现阶段以对症处理、延缓病情进展、预防器官损害和提高患者生活质量为主。根据本例患者的诊疗经过，我们认为制定适合的治疗方案和实施定期随访对患者预后大有裨益。

• Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with rare cases of bullous lesions. This paper reports a patient of SLE complicated with bullous lesions. The patient had SLE for 5 years. The overall control of the disease was stable during 4 years of follow-up, while sudden bullous lesion occurred, and was healed by the combination of traditional Chinese medicine and western medicine. The pathogenesis of SLE is complex and its etiology is not clear. At present, symptomatic treatment, delaying the progression of the disease, preventing organ damage and improving the quality of life of patients are the main factors for the disease. Based on this case, we believe that the development of an appropriate treatment plan and the implementation of regular follow-up are beneficial to the patient′s prognosis.