2023 年第 3 期 第 18 卷

铁死亡调控的关键因子在肾癌中的研究进展

Research progress of key factors of ferroptosis regulation in kidney cancer

作者：吴明哲1潘浩杰1周安安1肖喜1田俊强2

英文作者：Wu Mingzhe1 Pan Haojie1 Zhou An′an1 Xiao Xi1 Tian Junqiang2

单位：1兰州大学第二临床医学院，兰州730000；2兰州大学第二医院泌尿外科，兰州730000 通信作者：田俊强，Email：ery_tianjq@lzu.edu.cn

英文单位：1Second Clinical School of Lanzhou University Lanzhou 730000 China; 2Department of Urology Lanzhou University Second Hospital Lanzhou 730000 China

关键词：铁死亡；肾癌；调控机制；关键因子

英文关键词：Ferroptosis；Kidneycancer；Regulatorymechanism；Keyfactor

• 摘要：

• 铁死亡是一种铁依赖性的，区别于细胞凋亡、坏死、自噬、焦亡的新型细胞程序性死亡方式。铁死亡对肿瘤的发生发展有重要影响，诱导铁死亡在肿瘤的治疗方面表现出良好的应用前景。近年研究表明肾癌对铁死亡有较高的敏感性，铁死亡调控的一些关键因子如谷胱甘肽过氧化物酶4、VHL、核受体共激活因子4、TAZ等，可以通过靶向诱导或者抑制铁死亡，进而调控肾癌的发生发展。因此，本文对铁死亡调控的关键因子与肾癌的关系进行综述，这将有助于我们进一步了解铁死亡与肾癌之间的联系，进而为肾癌的治疗提供新的靶点及思路。

• Ferroptosis is an iron-dependent, novel form of programmed cell death that is distinct from apoptosis, necrosis, autophagy, and pyroptosis. Ferroptosis has an important impact on tumor development, and induction of ferroptosis has shown promising applications in the treatment of tumors. Recent studies have shown that kidney cancer has a high sensitivity to ferroptosis. Some key factors of iron death regulation, such as glutathione peroxidase 4, VHL, nuclear receptor coactivator 4 and TAZ, can be targeted to induce or inhibit ferroptosis and thus regulate the development of kidney cancer. Therefore, this paper reviews the relationship between key factors of ferroptosis regulation and kidney cancer, which will help us to further understand the link between ferroptosis and kidney cancer, and then provide new targets and ideas for the treatment of kidney cancer.