2023 年第 3 期 第 18 卷

肿瘤中环状RNA泛素结合相关蛋白2的表达及调控作用研究进展

Research progress on expression and regulatory mechanism of circular RNA ubiquitin binding associated protein 2 in tumors

作者：王海存高欣刘广麟姜兴明

英文作者：Wang Haicun Gao Xin Liu Guanglin Jiang Xingming

单位：哈尔滨医科大学附属第二医院普通外科，哈尔滨150086

英文单位：Department of General Surgery the 2nd Affiliated Hospital of Harbin Medical University Harbin 150086 China

关键词：肿瘤；环状RNA；泛素结合相关蛋白2；表达；调控作用

英文关键词：Tumors;CircularRNA;Ubiquitinbindingassociatedprotein2;Expression;Regulatorymechanism

• 摘要：

• 泛素结合相关蛋白2（UBAP2）是一种新发现的环状RNA，其在诸多人类肿瘤中异常表达并能参与调控肿瘤恶性生物学行为进程如肿瘤细胞的增殖、侵袭转移、抗凋亡和上皮间质转化等。环状RNA UBAP2（circ-UBAP2）的异常表达也与肿瘤的淋巴结转移、TNM分期、微血管浸润等病理特征有关；并且circ-UBAP2与环状RNA临床应用的研究热点如调控肿瘤细胞自噬、诱导细胞放疗和化疗耐受等也紧密相关。本文就circ-UBAP2在肿瘤中的表达、生物学作用及调控机制进行综述。

• Ubiquitin binding associated protein 2 (UBAP2) is a newly discovered circular RNA, which is aberrantly expressed in many human tumors and is involved in the regulation of malignant biological processes such as tumor cell proliferation, invasion, metastasis, anti-apoptosis, epithelial-mesenchymal transformation and so on. Abnormal expression of circular RNA UBAP2 (circ-UBAP2) is associated with pathological characteristics of tumors, such as lymph node metastasis, TNM stage and microvascular invasion. Moreover, circ-UBAP2 is also closely related to the research hotspots of circular RNA clinical application, such as regulating tumor cell autophagy, inducing cell radiotherapy and chemotherapy tolerance. This paper reviews the expression, biological and regulatory mechanism of circ-UBAP2 in tumors.