2023 年第 1 期 第 18 卷

常见信号通路在慢性阻塞性肺疾病发病机制中的研究进展

Research progress of common signaling pathways in the pathogenesis of chronic obstructive pulmonary disease

作者：白亚虎 董延春宁康

英文作者：Bai Yahu Dong Yanchun Ning Kang

单位：山东第一医科大学第一附属医院呼吸与危重症医学科，济南250014

英文单位：Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Shandong First Medical University Jinan 250014 China

关键词：慢性阻塞性肺疾病；信号通路；发病机制；靶点

英文关键词：Chronicobstructivepulmonarydisease;Signalingpathway;Pathogenesis;Target

• 摘要：

• 慢性阻塞性肺疾病（COPD）是气道、肺部慢性炎症性疾病，一般认为其炎症反应是由多种炎症细胞和化学趋化因子共同参与的，同时，参与炎症反应的信号通路十分复杂，且各个通路之间可能存在着联系。目前，常见的信号通路包括以下5种：Toll 样受体信号通路、 酪氨酸激酶/信号转导与转录激活因子信号通路、磷脂酰肌醇-3-激酶/蛋白激酶B信号通路、p38丝裂原活化蛋白激酶信号通路及核因子κB信号通路。本文对这5种信号通路在COPD发病机制中的作用进行综述，为临床发现治疗或延缓COPD的靶点提供参考。

• Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of airway and lung, and the inflammatory response is jointly participated by a variety of inflammatory cells and chemical chemokines. At the same time, the signaling pathways involved in inflammatory response are very complex, and there may be various interrelations among various pathways. At present, there are 5 common signaling pathways, including Toll-like receptors signaling pathway, tyrosine kinases/signal transducer and activator of transcription factor signaling pathway, phosphatidylinositol-3-kinase/protein kinase B signaling pathway, p38 mitogen activated protein kinase signaling pathway, and nuclear factor-κB signaling pathway. This paper reviews the role of these 5 signaling pathways in the pathogenesis of COPD, so as to provide reference for clinical discovery of targets to treatment or delay of COPD.