2023 年第 2 期 第 18 卷

白细胞介素1β在神经胶质瘤恶性进展中作用的研究进展

Research progress on the role of interleukin-1β in the malignant progression of gliomas

作者：王棒吴娟陈硕硕程哲束汉生

英文作者：Wang Bang Wu Juan Chen Shuoshuo Cheng Zhe Shu Hansheng

单位：蚌埠医学院第二附属医院神经外科，蚌埠233000

英文单位：Department of Neurosurgery the Second Affiliated Hospital of Bengbu Medical College Bengbu 233000 China

关键词：神经胶质瘤；恶性进展；白细胞介素1β

英文关键词：Glioma;Malignantprogression;Interleukin-1β

• 摘要：

• 白细胞介素1β（IL-1β）是一种多效性细胞因子，是启动免疫反应的关键因子，同时它也是炎症性肿瘤微环境中的中心介质。近年来的许多研究表明IL-1β在很多系统的肿瘤疾病中包括神经胶质瘤的发生发展中发挥重要作用，深入了解IL-1β在神经胶质瘤中的作用及其机制，可以为以IL-1β为靶点的抗胶质瘤治疗策略提供新的依据。本文对IL-1β在神经胶质瘤恶性进展中的作用进行综述。

• Interleukin-1β (IL-1β) is a multipotent cytokine, which is the key factor to initiate immune response, and it is also the central mediator in inflammatory tumor microenvironment. In recent years, many studies have shown that IL-1β plays an important role in the occurrence and development of many systematic tumor diseases, including gliomas. An in-depth understanding of the role and mechanism of IL-1β in gliomas can provide a new basis for anti-glioma therapy strategies targeting IL-1β. This article reviews the role of IL-1β in the malignant progression of gliomas.