2022 年第 11 期 第 17 卷

脂肪细胞外泌体在恶性肿瘤中作用的研究进展

Research progress of adipocyte-derived exosomes on malignant tumor

作者：田武国陈懿

英文作者：Tian Wuguo Chen Yi

单位：陆军军医大学大坪医院乳腺甲状腺外科，重庆400042

英文单位：Department of Breast and Thyroid Surgery Daping Hospital Army Medical University Chongqing 400042 China

关键词：脂肪细胞；外泌体；恶性肿瘤；肿瘤微环境

英文关键词：Adipocyte;Exosome;Malignanttumor;Tumormicroenvironment

• 摘要：

• 脂肪细胞作为肿瘤微环境中的一种细胞类型，其通过分泌脂肪细胞因子在肿瘤进展过程中与肿瘤细胞彼此沟通。近来研究表明，脂肪细胞衍生的外泌体因其在细胞间信息传递的强大能力而成为这一交流中的关键角色，脂肪细胞外泌体在促进恶性肿瘤增殖、侵袭、转移、化疗耐药和免疫治疗过程中发挥作用。本文就脂肪细胞外泌体在恶性肿瘤中的作用机制作一综述。

• As one of stromal cells within the tumor microenvironment, adipocytes communicate with cancer cells during tumor progression by secreting adipokines. Recent studies have shown that adipocyte-derived exosomes had emerged as new key actors in this communication due to their powerful capacity to convey complex messages between cells. Adipocyte-derived exosomes play a critical role to promote cancer proliferation, invasion, metastasis, chemotherapy resistance and immunotherapy of malignant tumor. Therefore, the mechanism of adipocyte-derived exosomes promote malignant tumor progression is reviewed as follow.