2022 年第 2 期 第 17 卷

生长分化因子15在脓毒症中表达的研究进展

Research progress of the expression of growth differentiation factor-15 in sepsis

作者：李欢汤冬玲张平安

英文作者：Li Huan Tang Dongling Zhang Ping′an

单位：武汉大学人民医院检验科，武汉430060

英文单位：Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan 430060 China

关键词：脓毒症；生长分化因子15；生物标志物

英文关键词：Sepsis;Growthdifferentiationfactor-15;Biomarker

• 摘要：

• 生长分化因子15（GDF-15）是一种肽类激素，是转化生长因子β超级家族的成员。在正常生理状态下，GDF-15在多个组织中低表达，而在组织损伤和炎症等病理过程中表达升高，GDF-15的异常表达与不同疾病的状态密切相关。脓毒症是机体对感染反应的失控导致的多器官功能障碍，近年来研究发现脓毒症患者血清GDF-15水平显著升高，提示GDF-15可能参与了脓毒症的发生发展，也可能是脓毒症的潜在生物标志物。本文对GDF-15在脓毒症中的研究进展进行综述。

• Growth differentiation factor-15 (GDF-15) is a peptide hormone and a member of the transforming growth factor-β super family. Under normal physiological conditions, GDF-15 is lowly expressed in many tissues, but it will increase in pathological processes such as tissue damage and inflammation. The abnormal expression of GDF-15 is closely related to the state of different diseases. Sepsis is a multiple organ dysfunction caused by the body′s uncontrolled response to infection. In recent years, studies have found that serum GDF-15 level significantly increases in patients with sepsis, suggesting that GDF-15 may be involved in the occurrence and development of sepsis, and may also be a potential biomarker of sepsis. This article reviews the research progress of GDF-15 in sepsis.