2021 年第 12 期 第 16 卷

孕烷X受体在部分糖脂代谢性疾病中的研究进展

Research progress of pregnane X receptor in some glycolipid metabolic diseases

作者：谢建华刘倩琦

英文作者：Xie Jianhua Liu Qianqi

单位：南京医科大学附属儿童医院儿童保健科210008

英文单位：Department of Child Health Care Children′s Hospital of Nanjing Medical University Nanjing 210008 China

关键词：糖脂代谢性疾病；孕烷X受体；肥胖；糖尿病；动脉粥样硬化；非酒精性脂肪性肝病

英文关键词：Glycolipidmetabolicdiseases;PregnaneXreceptor;Obesity;Diabetesmellitus;Atherosclerosis;Nonalcoholicfattyliverdisease

• 摘要：

• 糖脂代谢性疾病在人群中患病率日趋上升。孕烷X受体（PXR）是核受体家族中的成员之一，属于配体依赖性转录因子。PXR激活后可参与许多生理病理过程，在葡萄糖代谢、脂质代谢及稳态、胰岛素调节等方面发挥重要的作用。近年来PXR在糖脂代谢性疾病研究领域成为研究热点。PXR与肥胖、糖尿病、动脉粥样硬化、非酒精性脂肪性肝病等糖脂代谢性疾病密切相关，并且有望成为诊断这些疾病的新颖生物标志物和治疗靶点。本文简要阐述PXR在肥胖、糖尿病、动脉粥样硬化及非酒精性脂肪性肝病中的研究进展。

• The incidence of glycolipid metabolic diseases are increasing in the population. Pregnane X receptor(PXR) is a member of the nuclear receptor family and is a ligand-dependent transcription factor. After activation, PXR can participate in many diverse aspects of physiology and pathophysiology and plays an important role in glucose metabolism, lipid metabolism and homeostasis, insulin regulation and other aspects. In recent years, PXR has become a research hotspot in the field of glycolipid metabolic diseases. PXR is closely related to obesity, diabetes mellitus, atherosclerosis, nonalcoholic fatty liver disease and other glycolipid metabolic diseases. In addition, PXR is expected to be a novel biomarker and therapeutic target for the diagnosis of these diseases. This article briefly reviews the research progress of PXR in obesity, diabetes mellitus, atherosclerosis and nonalcoholic fatty liver disease.