2021 年第 10 期 第 16 卷

长链非编码RNA神经母细胞瘤相关转录本1在肿瘤中表达的研究进展

Research progress on expression of long non-coding RNA neuroblastoma associated transcript 1 in tumors

作者：边攀1寇邦国1蒋永杰1李兵太1杨小萍2尹兰宁1

英文作者：Bian Pan1 Kou Bangguo1 Jiang Yongjie1 Li Bingtai1 Yang Xiaoping2 Yin Lanning1

单位：1兰州大学第二医院普外科730000；2兰州大学第二医院消化内科730000

英文单位：1Department of General Surgery Lanzhou University Second Hospital Lanzhou 730000 China; 2Department of Gastroenterology Lanzhou University Second Hospital Lanzhou 730000 China

关键词：肿瘤；长链非编码RNA；神经母细胞瘤相关转录本1；研究进展

英文关键词：Tumors;Longnon-codingRNA;Neuroblastomaassociatedtranscript1;Research progress

• 摘要：

• 长链非编码RNA是一组长度超过200个核苷酸、没有蛋白编码功能的RNA转录本，在肿瘤发生过程中发挥着重要作用。神经母细胞瘤相关转录本1（NBAT1）是位于6p22号染色体局部扩增区的新型长链非编码RNA，在多种肿瘤组织中表达下调，低表达的NBAT1通常预示着患者预后不良。NBAT1参与细胞增殖、侵袭、转移、凋亡、细胞周期的调控和化疗耐药等与癌变相关的过程。本文对NBAT1在不同肿瘤发生发展中的作用及其分子机制进行综述，为肿瘤的早期诊断和靶向治疗提供新的研究方向。

• Long non-coding RNA (lncRNA), a group of RNA transcripts with more than 200 nucleotides in length and no protein coding function, plays an important role in tumorigenesis. Neuroblastoma associated transcript 1 (NBAT1) is a novel lncRNA located in the local amplification region of chromosome 6p22, and its expression is down-regulated in a variety of tumor tissues. Low expression of NBAT1 usually indicates a poor prognosis. At the same time, NBAT1 is involved in several cancer-related processes, such as cell proliferation, invasion, metastasis, apoptosis, cell cycle, and chemotherapy resistance. This paper reviews the role and molecular mechanism of NBAT1 in the development and progression of different cancers, which provides a new direction for the research of early diagnosis and targeted therapy of tumors. 0;font-family:宋体;mso-ascii-font-family:Calibri; mso-hansi-font-family:Calibri;mso-bidi-font-family:"Times New Roman"; mso-font-kerning:1px;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN; mso-bidi-language:AR-SA'>；研究进展 450052； 5陕西丽彩药业有限公司市场部，陕西省咸阳市 712000； 6郑州大学第一附属医院中医药学部 450052