2021 年第 10 期 第 16 卷

血清降钙素原水平在非感染因素所致心力衰竭患者病程中的变化

Changes of procalcitonin in the course of patients with heart failure caused by noninfectious factors

作者：左路广1张惠2谢桂芳3连晶晶1

英文作者：Zuo Luguang1 Zhang Hui2 Xie Guifang3 Lian Jingjing1

单位：1河北北方学院附属第一医院检验科，河北省张家口市075000；2河北中医骨病医院检验科，石家庄050000；3河北省张家口市第一医院检验科075000 

英文单位：1Department of Clinical Laboratory the First Affiliated Hospital of Hebei North University Hebei Province Zhangjiakou 075000 China; 2Department of Clinical Laboratory Hebei Orthopedic Hospital of Traditional Chinese Medicine Shijiazhuang 050000 China; 3Department of Clinical Laboratory the First Hospital of Zhangjiakou Hebei Province Zhangjiakou 075000 China

关键词：心力衰竭；非感染；降钙素原；心功能改善；病程 

英文关键词：Heartfailure;Noninfectious;Procalcitonin;Improvementofcardiacfunction;Diseasecoursehangjiakou,HebeiProvince,Zhangjiakou075000,China

• 摘要：

• 目的  研究血清降钙素原水平在非感染因素所致心力衰竭患者病程中的变化。方法 选取河北北方学院附属第一医院2019年1—12月收治入院的126例非感染因素所致慢性心力衰竭患者作为研究对象(观察组)，另选取同期慢性心力衰竭合并感染患者(感染组)、健康体检者(对照组)各100例。收集各组降钙素原水平并比较差异。分析观察组心功能改善前后血清降钙素原水平差异进而研究其在非感染因素心力衰竭病程中的变化趋势。结果 感染组血清降钙素原水平明显高于观察组和对照组［4.69(2.83，5.79)μg/L比1.95(1.59，2.39)、0.05(0.02，0.08)μg/L］，观察组血清降钙素原水平明显高于对照组，差异均有统计学意义(均P＜0.05)。观察组患者心功能改善后血清降钙素原水平明显低于治疗前［1.45(1.15，1.70)μg/L比1.95(1.59，2.39)μg/L］，差异有统计学意义（Z=106.21,P＜0.01）。非感染因素心力衰竭患者血清降钙素原水平随治疗干预延展呈逐渐下降趋势(H=588.82，P＜0.05)。结论 非感染因素所致心力衰竭患者血清降钙素原水平随治疗干预呈逐渐下降趋势。血清降钙素原水平可作为非感染因素所致心力衰竭监测、评估预后的临床依据。

• Objective To study the changes of procalcitonin in the course of patients with heart failure caused by noninfectious factors. Methods From January to December 2019, 126 patients with chronic heart failure caused by noninfectious factors admitted to the First Affiliated Hospital of Hebei North University were selected as the research objects (observation group). Another 100 cases of chronic heart failure patients with infection (infection group) and 100 cases of healthy people undergoing physical examination (control group) in the same period were selected. The procalcitonin level of each group was collected and the difference was compared. The procalcitonin level before and after the improvement of cardiac function in the observation group was analyzed to study its change trend in the course of noninfectious heart failure. Results Procalcitonin level in infection group was significantly higher than that in observation group and control group［4.69(2.83，5.79)μg/L vs 1.95(1.59，2.39), 0.05(0.02，0.08)μg/L］, and that in observation group was significantly higher than that in control group (all P＜0.05). Procalcitonin level in observation group after cardiac function improvement was significantly lower than that before treatment［1.45(1.15，1.70)μg/L vs 1.95(1.59，2.39)μg/L］（Z=106.21,P＜0.01）. Procalcitonin level in patients with heart failure caused by noninfectious factors decreased gradually with treatment (H=588.82, P＜0.05). Conclusions  Procalcitonin level in patients with heart failure caused by noninfectious factors decreased gradually with treatment. Procalcitonin can be used as a clinical basis for monitoring and evaluating prognosis of heart failure caused by noninfectious factors.